DHEA — a hormone produced by the adrenal glands — is a precursor to both male and female sex hormones, including estrogen and testosterone. DHEA plays a key role in supporting our overall health. It promotes muscle growth, improves bone density, and boosts our mood and libido. There's also evidence that DHEA might help improve skin health and cognitive function [1].
DHEA levels peak in our 20s and gradually decline as we age [2]. Unlike many other beneficial compounds, you can't significantly increase DHEA levels through your diet alone, as it isn't found in food. The only way to boost DHEA directly is through supplements, which are synthesized in laboratories.
However, supplementing with DHEA isn't without risks. It can cause hormonal imbalances, particularly if taken in high doses, leading to side effects such as oily skin, hair loss, and in more serious cases, liver damage. Women might experience changes like a deeper voice or facial hair growth, while men could face issues like breast enlargement. Plus, DHEA can interact with various medications, including those for diabetes and mood disorders, so it’s crucial to consult with a healthcare provider before starting any DHEA regimen, especially if you're currently on medication.
As for other supplements, DHEA shouldn't be mixed with ashwagandha, maca, or vitex, as it can overstimulate hormone production and lead to imbalances. It can also interact with other supplements that affect mood, such as 5-HTP or St. John's Wort, potentially causing mood swings or irritability. Additionally, combining DHEA with supplements that impact blood pressure, like hawthorn or magnesium, may cause blood pressure to drop too low.
