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Alcohol and Medications

Dangers of Mixing Ketamine and Alcohol

Published:
November 29, 2023
·
18 min read
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Written by
Reframe Content Team
A team of researchers and psychologists who specialize in behavioral health and neuroscience. This group collaborates to produce insightful and evidence-based content.
November 29, 2023
·
18 min read
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Certified recovery coach specialized in helping everyone redefine their relationship with alcohol. His approach in coaching focuses on habit formation and addressing the stress in our lives.
November 29, 2023
·
18 min read
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Recognized by Fortune and Fast Company as a top innovator shaping the future of health and known for his pivotal role in helping individuals change their relationship with alcohol.
November 29, 2023
·
18 min read
Reframe App LogoReframe App Logo
Reframe Content Team
November 29, 2023
·
18 min read

It’s Friday and you’re out with friends at the club. You and your friends all order drinks and you are dancing to the music. Everyone is having fun and your friends really want to match the energy of the club. So they ask if you want to take ketamine, a drug that’s popular for its dissociative effects. But you’ve been drinking, and you wonder if it’s a good idea to mix ketamine with alcohol. Is it potentially dangerous? To understand the dangers of mixing ketamine and alcohol, let’s explore the effects of ketamine and alcohol on our body. 

What Is Ketamine?

Ketamine was first created as an anesthesia to help with surgeries and pain relief. It’s known for its ability to induce dissociative anesthesia, making patients feel detached from their pain and environment. Over time, its use has expanded beyond anesthesia to treat various conditions, including depression and chronic pain. However, its recreational use has surged, and it became a drug that some people use for its mind-altering effects. 

In its pure form, ketamine exists as a white powder or a clear liquid and is often taken by swallowing, snorting, or injecting. You might have heard of ketamine by its street names like "Special K" or "K." Despite its hallucinogenic properties, ketamine is different from traditional hallucinogens like LSD or psilocybin. Instead of binding to serotonin receptors, ketamine primarily targets the glutamate system, specifically NMDA receptors in the brain.

When you take ketamine, it quickly dissolves into your bloodstream and goes to the brain. It acts as an antagonist to NMDA receptors, blocking the transmission of glutamate, a neurotransmitter important for learning, memory, and mood regulation. This interference is what causes a dissociative state, where your perceptions of sight and sound are distorted. It creates a strange feeling in which things don't seem real and you might see or hear things that aren't there, leading to a sense of detachment from reality. This dissociation, or “out of body” feeling, is why ketamine is sometimes referred to as a "dissociative anesthetic."

The Effects of Ketamine 

The effects of ketamine on your body depend on different factors.

  • Your size, weight and health
  • Your history with using ketamine
  • Whether you use other drugs in combination
  • The amount taken
  • The strength of the drug

The experience you have with ketamine can change depending on how much you take. Lower amounts might induce a “dreaming” feeling, while higher doses could lead to intense hallucinations and a feeling of being completely disconnected from reality. Common symptoms range from physical to psychological.

  • A sense of joy and calm
  • Dissociation (feeling disconnected from your body)
  • Hallucinations (seeing things or hearing sounds that aren't really there)
  • A faster heart rate and higher blood pressure
  • Confusion and clumsiness
  • Lack of body coordination or immobility
  • Involuntary rapid eye movement
  • Trouble speaking
  • Feeling anxious, panicked, or becoming aggressive
  • Nausea and/or vomiting
  • Reduced sensitivity to pain
  • In higher doses, a state known as the "K-hole," where the user experiences severe dissociation and immobility

Ketamine may also cause the following unwanted side effects.

  • Cognitive difficulties
  • Unconsciousness
  • Amnesia

Side effects like unconsciousness, amnesia, or immobility might be signs of ketamine overdose and require urgent medical attention. Make sure to look out for these signs if you or someone else is experiencing these symptoms. 

And if you’re taking medications, either over-the-counter or prescription, be aware they may interact with ketamine. Their side effects may be exacerbated, or their efficacy might be compromised. They can make ketamine use more dangerous. Please exercise caution!

Long-Term Effects of Ketamine

Ketamine's impact extends beyond its immediate, short-term effects. Prolonged use can lead to several long-term health issues.

  • Cognitive Impairment. Chronic use of ketamine has been linked to impairments in memory, attention, and executive functioning. These cognitive deficits can affect daily functioning and may persist even after discontinuing use.
  • Urinary Tract and Bladder Issues. One of the most significant long-term effects of ketamine use is its impact on the urinary system. Users may experience increased urgency and frequency of urination, pain while urinating, and, in severe cases, bladder inflammation and ulceration.
  • Gastrointestinal Distress. Regular use of ketamine can lead to chronic abdominal pain and other gastrointestinal issues, a condition sometimes referred to as "K-cramps."
  • Mental Health Problems. Long-term ketamine use has been associated with an increased risk of developing mental health disorders, including depression, anxiety, and in some cases, symptoms of psychosis. Some people have experienced hallucinogen persisting perception disorder (HPPD) weeks after taking ketamine. So it can have a prolonged effect on your sensory perception. 
  • Dependency and Tolerance. With regular use, we can develop tolerance to ketamine. When we become tolerant, we require larger doses to achieve the same effects, which may lead to dependence.

Ketamine Abuse and Misuse

According to the 2021 National Survey on Drug Use and Health, approximately 3 million people in the U.S. (aged 12 or older) reported using ketamine at least once in their lifetime. This percentage reflects the growing trend of recreational use. Ketamine abuse is more commonly reported among young adults aged 18 to 25, since they are often exposed to party scenes where recreational drug use is prevalent. Research suggests a correlation between ketamine misuse and mental health disorders: people with a history of mental health issues are at a higher risk of abusing substances like ketamine. More recently, ketamine has also received public attention as a novel treatment for certain psychiatric disorders

Mixing Ketamine and Alcohol

When ketamine is mixed with alcohol, the risks of danger escalate dramatically. Alcohol, a depressant, can amplify ketamine's sedative effects, leading to dangerous levels of respiratory depression. Using both in combination can have many harmful effects.

  • Exacerbated sedation and respiratory depression. Both alcohol and ketamine have sedative effects. Combining ketamine with alcohol amplifies the sedation and can dangerously slow down breathing and heart rate, increasing our risk for respiratory depression, which can be life-threatening.
  • Impaired cognitive and motor functions. The combination of alcohol and ketamine severely impairs cognitive and motor functions. This impairment can result in poor judgment, difficulty in making decisions, and a decrease in motor coordination. This then elevates the risk of accidents and injuries, as we become less capable of assessing risks and responding to our environment.
  • Increased risk of blackouts and memory loss. Both substances can disrupt our memory formation process. This can lead to blackouts, in which we cannot recall events that occurred while under the influence. These memory lapses can be distressing and may lead to dangerous situations where we may fail to have awareness or consent.
  • Heightened psychological distress. Ketamine can cause dissociative effects, including hallucinations and detachment from reality. When mixed with alcohol, these effects can become more intense and disorienting, potentially leading to anxiety, panic attacks, or exacerbation of pre-existing mental health conditions.
  • Risk of gastrointestinal distress. Alcohol is known to irritate the gastrointestinal tract, and ketamine can cause nausea and vomiting. The combination of these substances can increase the likelihood of gastrointestinal distress, which can lead to dehydration and electrolyte imbalance.
  • Potential for developing substance use disorders. Using multiple substances in combination increases the risk of developing substance use disorders. If you have alcohol use disorder, ketamine may add to the addictive potential. The interplay between the two can create a cycle of dependence and abuse, leading to long-term health and social consequences.
  • Dangerous interactions with other medications. When mixed with other medications, especially those that affect the central nervous system (such as antidepressants, anxiety medications, or other sedatives), the combination of alcohol and ketamine can lead to unpredictable and potentially harmful impairments.

Ketamine and Alcohol Overdose

Recognizing the symptoms of ketamine and alcohol abuse is important for early intervention.

  • Increased tolerance. Needing more of the substances to achieve the same effects.

  • Withdrawal symptoms. Experiencing physical or psychological symptoms when not using.

  • Neglect of responsibilities. Failing to meet professional, academic, or personal obligations.

  • Risky behavior. Engaging in dangerous activities while under the influence.

  • Social and relationship problems. Strained relationships and social isolation due to substance use.

  • Physical health issues. Experiencing health problems related to substance use, such as weight loss, gastrointestinal issues, or urinary tract problems.

  • Mental health deterioration. Worsening of mental health symptoms, including depression, anxiety, or hallucinations.

Alcohol with ketamine also increases the risk of overdose due to alcohol’s sedative effects on the body. There are potential signs of ketamine/alcohol overdose that you should look out for:

  • Seizures
  • Chest pains or trouble breathing
  • Unconsciousness
  • Impaired motor function
  • Confusion
  • Nausea or vomiting
  • High blood pressure
  • Slowed heart rate
  • Clammy skin
  • Low body temperature

If you or your loved ones are experiencing any of these symptoms, call 911 or reach out to your healthcare professional right away. Polysubstance abuse makes these effects more dangerous, leading to potential death. The probability of surviving an overdose involving both ketamine and alcohol is influenced by how much you took, your age, your health, and other factors. 

Substance abuse is a serious problem but there are other ways you can work on reclaiming your well-being and live a substance-free life. Read on to find out more!

Treatment for Ketamine and Alcohol Abuse

Effective treatment for ketamine abuse requires a comprehensive approach.

  • Detoxification and withdrawal management. The first step in treatment is often detoxification, which should be medically supervised to manage withdrawal symptoms safely.
  • Behavioral therapies. Cognitive-behavioral therapy (CBT) and other psychotherapies can help people understand their substance use triggers and develop healthier coping mechanisms.
  • Medication-Assisted Treatment (MAT). While there are no specific medications for ketamine abuse, MAT can help treat co-occurring disorders or symptoms.
  • Support groups and peer support. Groups like Narcotics Anonymous (NA) or other peer support groups can provide valuable social support and a sense of community.
  • Treatment of co-occurring disorders. Addressing any co-occurring mental health disorders is crucial for successful recovery.
  • Lifestyle changes. Encouraging healthy lifestyle choices, such as regular exercise, a balanced diet, and engaging in hobbies and interests, can support recovery.
  • Family therapy and support. Involving family members in the treatment process can improve outcomes and provide additional support.

Treatment should be tailored to the person’s specific needs, the severity of their substance use disorder, the presence of co-occurring conditions, and their personal circumstances. Professional help is critical in overcoming ketamine abuse and reclaiming a healthy, substance-free life.

Tips for Safety and Awareness

  • Educate yourself. Research the effects of ketamine and alcohol when combined. Understand the risks and consequences to make informed decisions. Join a supportive community like Reframe for science-backed advice on alcohol and alcohol related concerns to learn more about ways to improve your health.
  • Create boundaries. Set clear personal limits regarding substance use. Establishing boundaries helps in avoiding situations where mixing ketamine and alcohol might occur.
  • Seek support. Foster a supportive network of friends and family who are aware of your goals to decrease substance intake. A positive, understanding environment helps in making healthier choices.
  • Explore alternatives. Engage in activities and hobbies that provide fulfillment and joy without relying on substances. Discovering new passions can divert attention from potentially harmful behaviors.
  • Practice mindfulness. Incorporate mindfulness techniques such as meditation or deep breathing exercises to manage stress and cravings effectively.
  • Professional guidance. Consider seeking professional help or counseling to address underlying issues contributing to substance abuse.
  • Develop healthy coping mechanisms. Identify and adopt healthy coping strategies like regular exercise, journaling, or creative outlets to navigate challenging emotions without resorting to substance use.

Summing Up

Now that you understand the risks associated with mixing ketamine and alcohol, you can make informed, responsible choices to ensure your safety and the well-being of those around you. Remember, a night of fun should never compromise your health or future. Stay informed, stay safe, and help create a culture of awareness and responsibility! 

It’s Friday and you’re out with friends at the club. You and your friends all order drinks and you are dancing to the music. Everyone is having fun and your friends really want to match the energy of the club. So they ask if you want to take ketamine, a drug that’s popular for its dissociative effects. But you’ve been drinking, and you wonder if it’s a good idea to mix ketamine with alcohol. Is it potentially dangerous? To understand the dangers of mixing ketamine and alcohol, let’s explore the effects of ketamine and alcohol on our body. 

What Is Ketamine?

Ketamine was first created as an anesthesia to help with surgeries and pain relief. It’s known for its ability to induce dissociative anesthesia, making patients feel detached from their pain and environment. Over time, its use has expanded beyond anesthesia to treat various conditions, including depression and chronic pain. However, its recreational use has surged, and it became a drug that some people use for its mind-altering effects. 

In its pure form, ketamine exists as a white powder or a clear liquid and is often taken by swallowing, snorting, or injecting. You might have heard of ketamine by its street names like "Special K" or "K." Despite its hallucinogenic properties, ketamine is different from traditional hallucinogens like LSD or psilocybin. Instead of binding to serotonin receptors, ketamine primarily targets the glutamate system, specifically NMDA receptors in the brain.

When you take ketamine, it quickly dissolves into your bloodstream and goes to the brain. It acts as an antagonist to NMDA receptors, blocking the transmission of glutamate, a neurotransmitter important for learning, memory, and mood regulation. This interference is what causes a dissociative state, where your perceptions of sight and sound are distorted. It creates a strange feeling in which things don't seem real and you might see or hear things that aren't there, leading to a sense of detachment from reality. This dissociation, or “out of body” feeling, is why ketamine is sometimes referred to as a "dissociative anesthetic."

The Effects of Ketamine 

The effects of ketamine on your body depend on different factors.

  • Your size, weight and health
  • Your history with using ketamine
  • Whether you use other drugs in combination
  • The amount taken
  • The strength of the drug

The experience you have with ketamine can change depending on how much you take. Lower amounts might induce a “dreaming” feeling, while higher doses could lead to intense hallucinations and a feeling of being completely disconnected from reality. Common symptoms range from physical to psychological.

  • A sense of joy and calm
  • Dissociation (feeling disconnected from your body)
  • Hallucinations (seeing things or hearing sounds that aren't really there)
  • A faster heart rate and higher blood pressure
  • Confusion and clumsiness
  • Lack of body coordination or immobility
  • Involuntary rapid eye movement
  • Trouble speaking
  • Feeling anxious, panicked, or becoming aggressive
  • Nausea and/or vomiting
  • Reduced sensitivity to pain
  • In higher doses, a state known as the "K-hole," where the user experiences severe dissociation and immobility

Ketamine may also cause the following unwanted side effects.

  • Cognitive difficulties
  • Unconsciousness
  • Amnesia

Side effects like unconsciousness, amnesia, or immobility might be signs of ketamine overdose and require urgent medical attention. Make sure to look out for these signs if you or someone else is experiencing these symptoms. 

And if you’re taking medications, either over-the-counter or prescription, be aware they may interact with ketamine. Their side effects may be exacerbated, or their efficacy might be compromised. They can make ketamine use more dangerous. Please exercise caution!

Long-Term Effects of Ketamine

Ketamine's impact extends beyond its immediate, short-term effects. Prolonged use can lead to several long-term health issues.

  • Cognitive Impairment. Chronic use of ketamine has been linked to impairments in memory, attention, and executive functioning. These cognitive deficits can affect daily functioning and may persist even after discontinuing use.
  • Urinary Tract and Bladder Issues. One of the most significant long-term effects of ketamine use is its impact on the urinary system. Users may experience increased urgency and frequency of urination, pain while urinating, and, in severe cases, bladder inflammation and ulceration.
  • Gastrointestinal Distress. Regular use of ketamine can lead to chronic abdominal pain and other gastrointestinal issues, a condition sometimes referred to as "K-cramps."
  • Mental Health Problems. Long-term ketamine use has been associated with an increased risk of developing mental health disorders, including depression, anxiety, and in some cases, symptoms of psychosis. Some people have experienced hallucinogen persisting perception disorder (HPPD) weeks after taking ketamine. So it can have a prolonged effect on your sensory perception. 
  • Dependency and Tolerance. With regular use, we can develop tolerance to ketamine. When we become tolerant, we require larger doses to achieve the same effects, which may lead to dependence.

Ketamine Abuse and Misuse

According to the 2021 National Survey on Drug Use and Health, approximately 3 million people in the U.S. (aged 12 or older) reported using ketamine at least once in their lifetime. This percentage reflects the growing trend of recreational use. Ketamine abuse is more commonly reported among young adults aged 18 to 25, since they are often exposed to party scenes where recreational drug use is prevalent. Research suggests a correlation between ketamine misuse and mental health disorders: people with a history of mental health issues are at a higher risk of abusing substances like ketamine. More recently, ketamine has also received public attention as a novel treatment for certain psychiatric disorders

Mixing Ketamine and Alcohol

When ketamine is mixed with alcohol, the risks of danger escalate dramatically. Alcohol, a depressant, can amplify ketamine's sedative effects, leading to dangerous levels of respiratory depression. Using both in combination can have many harmful effects.

  • Exacerbated sedation and respiratory depression. Both alcohol and ketamine have sedative effects. Combining ketamine with alcohol amplifies the sedation and can dangerously slow down breathing and heart rate, increasing our risk for respiratory depression, which can be life-threatening.
  • Impaired cognitive and motor functions. The combination of alcohol and ketamine severely impairs cognitive and motor functions. This impairment can result in poor judgment, difficulty in making decisions, and a decrease in motor coordination. This then elevates the risk of accidents and injuries, as we become less capable of assessing risks and responding to our environment.
  • Increased risk of blackouts and memory loss. Both substances can disrupt our memory formation process. This can lead to blackouts, in which we cannot recall events that occurred while under the influence. These memory lapses can be distressing and may lead to dangerous situations where we may fail to have awareness or consent.
  • Heightened psychological distress. Ketamine can cause dissociative effects, including hallucinations and detachment from reality. When mixed with alcohol, these effects can become more intense and disorienting, potentially leading to anxiety, panic attacks, or exacerbation of pre-existing mental health conditions.
  • Risk of gastrointestinal distress. Alcohol is known to irritate the gastrointestinal tract, and ketamine can cause nausea and vomiting. The combination of these substances can increase the likelihood of gastrointestinal distress, which can lead to dehydration and electrolyte imbalance.
  • Potential for developing substance use disorders. Using multiple substances in combination increases the risk of developing substance use disorders. If you have alcohol use disorder, ketamine may add to the addictive potential. The interplay between the two can create a cycle of dependence and abuse, leading to long-term health and social consequences.
  • Dangerous interactions with other medications. When mixed with other medications, especially those that affect the central nervous system (such as antidepressants, anxiety medications, or other sedatives), the combination of alcohol and ketamine can lead to unpredictable and potentially harmful impairments.

Ketamine and Alcohol Overdose

Recognizing the symptoms of ketamine and alcohol abuse is important for early intervention.

  • Increased tolerance. Needing more of the substances to achieve the same effects.

  • Withdrawal symptoms. Experiencing physical or psychological symptoms when not using.

  • Neglect of responsibilities. Failing to meet professional, academic, or personal obligations.

  • Risky behavior. Engaging in dangerous activities while under the influence.

  • Social and relationship problems. Strained relationships and social isolation due to substance use.

  • Physical health issues. Experiencing health problems related to substance use, such as weight loss, gastrointestinal issues, or urinary tract problems.

  • Mental health deterioration. Worsening of mental health symptoms, including depression, anxiety, or hallucinations.

Alcohol with ketamine also increases the risk of overdose due to alcohol’s sedative effects on the body. There are potential signs of ketamine/alcohol overdose that you should look out for:

  • Seizures
  • Chest pains or trouble breathing
  • Unconsciousness
  • Impaired motor function
  • Confusion
  • Nausea or vomiting
  • High blood pressure
  • Slowed heart rate
  • Clammy skin
  • Low body temperature

If you or your loved ones are experiencing any of these symptoms, call 911 or reach out to your healthcare professional right away. Polysubstance abuse makes these effects more dangerous, leading to potential death. The probability of surviving an overdose involving both ketamine and alcohol is influenced by how much you took, your age, your health, and other factors. 

Substance abuse is a serious problem but there are other ways you can work on reclaiming your well-being and live a substance-free life. Read on to find out more!

Treatment for Ketamine and Alcohol Abuse

Effective treatment for ketamine abuse requires a comprehensive approach.

  • Detoxification and withdrawal management. The first step in treatment is often detoxification, which should be medically supervised to manage withdrawal symptoms safely.
  • Behavioral therapies. Cognitive-behavioral therapy (CBT) and other psychotherapies can help people understand their substance use triggers and develop healthier coping mechanisms.
  • Medication-Assisted Treatment (MAT). While there are no specific medications for ketamine abuse, MAT can help treat co-occurring disorders or symptoms.
  • Support groups and peer support. Groups like Narcotics Anonymous (NA) or other peer support groups can provide valuable social support and a sense of community.
  • Treatment of co-occurring disorders. Addressing any co-occurring mental health disorders is crucial for successful recovery.
  • Lifestyle changes. Encouraging healthy lifestyle choices, such as regular exercise, a balanced diet, and engaging in hobbies and interests, can support recovery.
  • Family therapy and support. Involving family members in the treatment process can improve outcomes and provide additional support.

Treatment should be tailored to the person’s specific needs, the severity of their substance use disorder, the presence of co-occurring conditions, and their personal circumstances. Professional help is critical in overcoming ketamine abuse and reclaiming a healthy, substance-free life.

Tips for Safety and Awareness

  • Educate yourself. Research the effects of ketamine and alcohol when combined. Understand the risks and consequences to make informed decisions. Join a supportive community like Reframe for science-backed advice on alcohol and alcohol related concerns to learn more about ways to improve your health.
  • Create boundaries. Set clear personal limits regarding substance use. Establishing boundaries helps in avoiding situations where mixing ketamine and alcohol might occur.
  • Seek support. Foster a supportive network of friends and family who are aware of your goals to decrease substance intake. A positive, understanding environment helps in making healthier choices.
  • Explore alternatives. Engage in activities and hobbies that provide fulfillment and joy without relying on substances. Discovering new passions can divert attention from potentially harmful behaviors.
  • Practice mindfulness. Incorporate mindfulness techniques such as meditation or deep breathing exercises to manage stress and cravings effectively.
  • Professional guidance. Consider seeking professional help or counseling to address underlying issues contributing to substance abuse.
  • Develop healthy coping mechanisms. Identify and adopt healthy coping strategies like regular exercise, journaling, or creative outlets to navigate challenging emotions without resorting to substance use.

Summing Up

Now that you understand the risks associated with mixing ketamine and alcohol, you can make informed, responsible choices to ensure your safety and the well-being of those around you. Remember, a night of fun should never compromise your health or future. Stay informed, stay safe, and help create a culture of awareness and responsibility! 

Summary FAQs

1. What is ketamine, and why is it risky to mix with alcohol?

Ketamine is a dissociative anesthetic used in both medical and recreational contexts. Mixing it with alcohol is risky because it amplifies the sedative effects, leading to severe respiratory depression, cognitive impairment, and increased risk of accidents.

2. What are the short-term effects of using ketamine?

Short-term effects include altered perception, dissociation, hallucinations, changes in sensory perception, short-term amnesia, and, in high doses, a state called the "K-hole."

3. Can using ketamine and alcohol together affect my mental health?

Yes, combining these substances can exacerbate mental health issues, leading to heightened psychological distress, anxiety, and potential exacerbation of existing mental health conditions.

4. What are some long-term effects of ketamine abuse?

Long-term effects include cognitive impairment, urinary tract and bladder issues, gastrointestinal distress, mental health problems, and the risk of dependency and tolerance.

5. How can I recognize if someone is abusing ketamine and alcohol?

Look for signs like increased tolerance, withdrawal symptoms, neglect of responsibilities, risky behavior, relationship problems, physical health issues, and deterioration in mental health.

6. What treatments are available for ketamine abuse?

Treatments include medically supervised detoxification, behavioral therapies like CBT, medication-assisted treatment for co-occurring disorders, support groups, addressing co-occurring mental health disorders, making lifestyle changes, and family therapy.

7. How can I protect myself and others from the dangers of mixing ketamine and alcohol?

Educate yourself and others about the risks, monitor substance consumption, avoid mixing substances, have a safety plan when going out, seek professional help if needed, be a responsible friend, and stay informed about local resources.

Avoid the Dangers of Ketamine and Alcohol With Reframe!

Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually, with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!

The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.

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The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app through the App Store or Google Play today!

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