Drinking on Xtandi leads to negative effects despite no direct interactions. Check out our latest blog for more info on how alcohol adds fuel to the fire of Xtandi’s side effects.
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually, with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app through the App Store or Google Play today!
Prostate cancer affects a shocking 13% of men, but luckily it has a high successful treatment rate. Common treatments include active monitoring, radiation therapy, surgery, and hormone therapy. However, these treatments aren’t always effective. When prostate cancer progresses toward more advanced stages and nothing seems to be working, that’s when Xtandi can come in handy.
Xtandi is an effective treatment for high-risk prostate cancer, but it can interact with many other drugs and substances. Avoiding these interactions can be a bit like walking through a minefield — trying hard not to trigger a reaction. Let’s better understand Xtandi’s interactions to clear a path for safe consumption.
Xtandi is a prescription medication that’s used to treat certain types of advanced prostate cancer. It’s approved for two types of prostate cancer:
Xtandi contains the drug enzalutamide, which belongs to a class of drugs called androgen receptor inhibitors. These drugs prevent the cancer from spreading by blocking the effects of androgens (male hormones). Those who are prescribed Xtandi should have already completed surgery to remove the testicles (orchiectomy), or have been taking another drug that lowers testosterone levels for full effectiveness of Xtandi.
Clinical studies showed that in men with metastatic prostate cancer that no longer improved with medication or surgery, Xtandi (or enzalutamide) led to a 71% lower risk of the cancer spreading. In a group of men with nonmetastatic prostate cancer, Xtandi had an 83% lower risk of the cancer worsening in comparison to a group taking a placebo. Although Xtandi is an effective medication, it’s associated with potential side effects.
Xtandi can cause a range of mild to severe side effects. Common side effects include:
If these mild side effects worsen or don’t subside after a few weeks, talk to your doctor. Serious side effects are less common but can occur:
If you’re experiencing any severe side effects, call 9-1-1 for emergency medical attention. Xtandi is already associated with many side effects, but when we add alcohol to the equation, things can get even more serious.
Xtandi, like all medications, is associated with side effects. However, mixing Xtandi and alcohol can be a whole different ball game.
In short, alcohol adds fuel to the risks of Xtandi. Mixing the two could lead to double the trouble. Here’s why:
Alcohol and Xtandi have many overlapping side effects:
As we can see, alcohol adds fuel to the fire — worsening side effects. But there’s even more to consider!
Both Xtandi and alcohol are processed by the liver. When we drink, our liver prioritizes getting rid of the toxins from alcohol (for good reason). However, since our liver is in overdrive with having to deal with more than one thing at a time, it gives the toxins more time to linger. This can lead to increased side effects and hangover symptoms.
Putting our liver into overdrive not only leads to negative short-term effects, but also causes long-term liver damage. Over time, constant stress can lead to liver dysfunction and disease. To learn more about how quickly this can happen, check out “How Much Alcohol Causes Liver Damage?”
Xtandi works by blocking the action of male hormones. This slows prostate cancer growth and promotes cancer cell death. Alcohol, on the other hand, imbalances our hormones, disrupting the mechanism of Xtandi.
In small amounts, alcohol can increase the production of testosterone (a type of androgen). Over time however, alcohol has the opposite effect on testosterone. While this may sound like it works in our favor (for the sake of inhibiting androgens to treat prostate cancer), fluctuations in our testosterone only lead to greater hormonal imbalance. In fact, research shows that hormonal imbalance is one of the causes of prostate cancer. Want to learn more about alcohol’s effects on our hormones? Check out “How Does Quitting Alcohol Help Your Hormones?”
Another risk of mixing Xtandi and alcohol? Poor mental health. While Xtandi alone isn’t associated with mental health issues, prostate cancer is. Significant mental health problems such as depression, anxiety, fear of cancer recurrence, and self-esteem issues are prevalent among those diagnosed with prostate cancer.
Similarly, alcohol is also associated with a host of mental health issues. Alcohol hijacks chemical messengers (neurotransmitters in our brain) that influence our mood. While we may feel a temporary boost in mood when we’re drinking, the depressant aftereffects increase the risk of mental health conditions such as anxiety, depression, and mood disorders. To get a more in-depth look at alcohol’s psychological impacts, take a look at “Understanding Alcohol’s Effects on Mental Health.”
Lastly, Xtandi and alcohol both interact with many other substances. Xtandi is commonly used in conjunction with other treatments to help attack prostate cancer on all fronts. For example, high-energy radiation used to destroy cancer cells (radiation therapy) is often used with Xtandi. Physicians recommend avoiding alcohol during radiation therapy, as it can make the experience even more unpleasant. Recovery from prostate cancer can include much more than Xtandi, increasing the chances of negative interactions when we choose to drink.
To make matters more complicated, alcohol affects our inhibitions and judgment. Recall the long list of interactions printed on the warning label of Xtandi? Or the reminder from the doctor not to mix certain medications with alcohol? Well, alcohol can make these directions a bit fuzzy in our minds — and as a result, we may end up mixing substances that have dangerous interactions. What else should we take into consideration when taking Xtandi?
In addition to clashing with alcohol, Xtandi interacts with many other medications. Let’s get a better idea of what they are and how alcohol further complicates things.
Buspirone is a medication used to treat anxiety disorders by balancing the hormones that control our mood. Xtandi speeds up the breakdown of buspirone, leading to lower levels of the medication in our body — and as a result, decreases the effectiveness of buspirone.
Alcohol and buspirone are also not a good mix. Since there aren’t any direct interactions, you may be wondering, “Can you drink while taking buspirone?” The short answer is no. Mixing alcohol with buspirone can lead to worsened side effects such as dizziness, drowsiness, difficulty breathing, and confusion. Additionally, alcohol negatively impacts anxiety, indirectly impacting buspirone. In short, alcohol, buspirone, and Xtandi are an incompatible combination.
Benzodiazepines are a class of depressant drugs used to treat anxiety, seizures, and other conditions. They work by slowing down activity in our brain and nervous system. Xtandi decreases levels of the benzodiazepines in our body, making them less effective and increasing the risk of benzodiazepine withdrawal.
Do the depressant effects of benzodiazepines sound familiar? That’s because alcohol is also a depressant that causes similar effects on our central nervous system (CNS). Mixing the alcohol and benzodiazepines amplifies their dangers including exacerbated side effects, increased risk of overdose, and increased risk of dependence.
This class of drugs reduces anxiety and induces calming effects, which is helpful in treating insomnia or other sleep disorders. Xtandi impacts the effectiveness of sedative-hypnotics, as it promotes speedier breakdown of the drugs.
Mixing alcohol and sedative-hypnotics is also a bad idea. Like benzodiazepines, sedative-hypnotics are also CNS depressants that act on the same system as alcohol. Drinking while taking sedative-hypnotics increases their depressant effects, risk of overdose, and risk of dependence.
Before starting Xtandi, it’s important to discuss with our physician which prescription medications, over-the-counter medications, and other substances we’re taking. Aside from the more obvious prescription medications, let’s see what else we need to make note of.
Aside from prescription medications, Xtandi doesn’t mix well with several other substances:
To stay on the safe side, we should consult with our doctor if we’re taking or planning to take any of these substances.
The average half-life of Xtandi is 5.8 days or 6 to be safe. However, it takes about 5 half-lives for a medication to be completely eliminated from our system. It’s recommended to wait at least 30 days after stopping Xtandi to avoid the potential risks of mixing Xtandi and alcohol.
Waiting for the elimination period to pass before drinking is helpful in reducing indirect interactions between Xtandi and alcohol, but it’s important to note that drinking is still detrimental to our health. In regards to recovering from prostate cancer, alcohol imbalances our hormones and puts a damper on immune function — leading to an increased risk of cancer recurrence and impacted recovery. Let’s explore some ways we can approach Xtandi and alcohol more safely and mindfully.
Understanding Xtandi and alcohol’s interactions is one way we can prioritize our safety. Implementing mindful consumption strategies can further promote our health and safety:
Navigating prostate cancer and alcohol is no easy task. But remember that Reframe is here for you as you work towards a happier and healthier life. Be a part of our thriving community and connect with others who may share similar struggles. We can work together to support each other every step of the way!
Xtandi is an effective treatment for advanced prostate cancer, but navigating it safely can be a bit of a balancing act. It has interactions with other medications and substances, including alcohol. Drinking while taking Xtandi amplifies its side effects and opens the door to other potential risks. Luckily, we can minimize these risks by quitting or cutting back on alcohol. Exact the full effectiveness of Xtandi by avoiding interactions!
Prostate cancer affects a shocking 13% of men, but luckily it has a high successful treatment rate. Common treatments include active monitoring, radiation therapy, surgery, and hormone therapy. However, these treatments aren’t always effective. When prostate cancer progresses toward more advanced stages and nothing seems to be working, that’s when Xtandi can come in handy.
Xtandi is an effective treatment for high-risk prostate cancer, but it can interact with many other drugs and substances. Avoiding these interactions can be a bit like walking through a minefield — trying hard not to trigger a reaction. Let’s better understand Xtandi’s interactions to clear a path for safe consumption.
Xtandi is a prescription medication that’s used to treat certain types of advanced prostate cancer. It’s approved for two types of prostate cancer:
Xtandi contains the drug enzalutamide, which belongs to a class of drugs called androgen receptor inhibitors. These drugs prevent the cancer from spreading by blocking the effects of androgens (male hormones). Those who are prescribed Xtandi should have already completed surgery to remove the testicles (orchiectomy), or have been taking another drug that lowers testosterone levels for full effectiveness of Xtandi.
Clinical studies showed that in men with metastatic prostate cancer that no longer improved with medication or surgery, Xtandi (or enzalutamide) led to a 71% lower risk of the cancer spreading. In a group of men with nonmetastatic prostate cancer, Xtandi had an 83% lower risk of the cancer worsening in comparison to a group taking a placebo. Although Xtandi is an effective medication, it’s associated with potential side effects.
Xtandi can cause a range of mild to severe side effects. Common side effects include:
If these mild side effects worsen or don’t subside after a few weeks, talk to your doctor. Serious side effects are less common but can occur:
If you’re experiencing any severe side effects, call 9-1-1 for emergency medical attention. Xtandi is already associated with many side effects, but when we add alcohol to the equation, things can get even more serious.
Xtandi, like all medications, is associated with side effects. However, mixing Xtandi and alcohol can be a whole different ball game.
In short, alcohol adds fuel to the risks of Xtandi. Mixing the two could lead to double the trouble. Here’s why:
Alcohol and Xtandi have many overlapping side effects:
As we can see, alcohol adds fuel to the fire — worsening side effects. But there’s even more to consider!
Both Xtandi and alcohol are processed by the liver. When we drink, our liver prioritizes getting rid of the toxins from alcohol (for good reason). However, since our liver is in overdrive with having to deal with more than one thing at a time, it gives the toxins more time to linger. This can lead to increased side effects and hangover symptoms.
Putting our liver into overdrive not only leads to negative short-term effects, but also causes long-term liver damage. Over time, constant stress can lead to liver dysfunction and disease. To learn more about how quickly this can happen, check out “How Much Alcohol Causes Liver Damage?”
Xtandi works by blocking the action of male hormones. This slows prostate cancer growth and promotes cancer cell death. Alcohol, on the other hand, imbalances our hormones, disrupting the mechanism of Xtandi.
In small amounts, alcohol can increase the production of testosterone (a type of androgen). Over time however, alcohol has the opposite effect on testosterone. While this may sound like it works in our favor (for the sake of inhibiting androgens to treat prostate cancer), fluctuations in our testosterone only lead to greater hormonal imbalance. In fact, research shows that hormonal imbalance is one of the causes of prostate cancer. Want to learn more about alcohol’s effects on our hormones? Check out “How Does Quitting Alcohol Help Your Hormones?”
Another risk of mixing Xtandi and alcohol? Poor mental health. While Xtandi alone isn’t associated with mental health issues, prostate cancer is. Significant mental health problems such as depression, anxiety, fear of cancer recurrence, and self-esteem issues are prevalent among those diagnosed with prostate cancer.
Similarly, alcohol is also associated with a host of mental health issues. Alcohol hijacks chemical messengers (neurotransmitters in our brain) that influence our mood. While we may feel a temporary boost in mood when we’re drinking, the depressant aftereffects increase the risk of mental health conditions such as anxiety, depression, and mood disorders. To get a more in-depth look at alcohol’s psychological impacts, take a look at “Understanding Alcohol’s Effects on Mental Health.”
Lastly, Xtandi and alcohol both interact with many other substances. Xtandi is commonly used in conjunction with other treatments to help attack prostate cancer on all fronts. For example, high-energy radiation used to destroy cancer cells (radiation therapy) is often used with Xtandi. Physicians recommend avoiding alcohol during radiation therapy, as it can make the experience even more unpleasant. Recovery from prostate cancer can include much more than Xtandi, increasing the chances of negative interactions when we choose to drink.
To make matters more complicated, alcohol affects our inhibitions and judgment. Recall the long list of interactions printed on the warning label of Xtandi? Or the reminder from the doctor not to mix certain medications with alcohol? Well, alcohol can make these directions a bit fuzzy in our minds — and as a result, we may end up mixing substances that have dangerous interactions. What else should we take into consideration when taking Xtandi?
In addition to clashing with alcohol, Xtandi interacts with many other medications. Let’s get a better idea of what they are and how alcohol further complicates things.
Buspirone is a medication used to treat anxiety disorders by balancing the hormones that control our mood. Xtandi speeds up the breakdown of buspirone, leading to lower levels of the medication in our body — and as a result, decreases the effectiveness of buspirone.
Alcohol and buspirone are also not a good mix. Since there aren’t any direct interactions, you may be wondering, “Can you drink while taking buspirone?” The short answer is no. Mixing alcohol with buspirone can lead to worsened side effects such as dizziness, drowsiness, difficulty breathing, and confusion. Additionally, alcohol negatively impacts anxiety, indirectly impacting buspirone. In short, alcohol, buspirone, and Xtandi are an incompatible combination.
Benzodiazepines are a class of depressant drugs used to treat anxiety, seizures, and other conditions. They work by slowing down activity in our brain and nervous system. Xtandi decreases levels of the benzodiazepines in our body, making them less effective and increasing the risk of benzodiazepine withdrawal.
Do the depressant effects of benzodiazepines sound familiar? That’s because alcohol is also a depressant that causes similar effects on our central nervous system (CNS). Mixing the alcohol and benzodiazepines amplifies their dangers including exacerbated side effects, increased risk of overdose, and increased risk of dependence.
This class of drugs reduces anxiety and induces calming effects, which is helpful in treating insomnia or other sleep disorders. Xtandi impacts the effectiveness of sedative-hypnotics, as it promotes speedier breakdown of the drugs.
Mixing alcohol and sedative-hypnotics is also a bad idea. Like benzodiazepines, sedative-hypnotics are also CNS depressants that act on the same system as alcohol. Drinking while taking sedative-hypnotics increases their depressant effects, risk of overdose, and risk of dependence.
Before starting Xtandi, it’s important to discuss with our physician which prescription medications, over-the-counter medications, and other substances we’re taking. Aside from the more obvious prescription medications, let’s see what else we need to make note of.
Aside from prescription medications, Xtandi doesn’t mix well with several other substances:
To stay on the safe side, we should consult with our doctor if we’re taking or planning to take any of these substances.
The average half-life of Xtandi is 5.8 days or 6 to be safe. However, it takes about 5 half-lives for a medication to be completely eliminated from our system. It’s recommended to wait at least 30 days after stopping Xtandi to avoid the potential risks of mixing Xtandi and alcohol.
Waiting for the elimination period to pass before drinking is helpful in reducing indirect interactions between Xtandi and alcohol, but it’s important to note that drinking is still detrimental to our health. In regards to recovering from prostate cancer, alcohol imbalances our hormones and puts a damper on immune function — leading to an increased risk of cancer recurrence and impacted recovery. Let’s explore some ways we can approach Xtandi and alcohol more safely and mindfully.
Understanding Xtandi and alcohol’s interactions is one way we can prioritize our safety. Implementing mindful consumption strategies can further promote our health and safety:
Navigating prostate cancer and alcohol is no easy task. But remember that Reframe is here for you as you work towards a happier and healthier life. Be a part of our thriving community and connect with others who may share similar struggles. We can work together to support each other every step of the way!
Xtandi is an effective treatment for advanced prostate cancer, but navigating it safely can be a bit of a balancing act. It has interactions with other medications and substances, including alcohol. Drinking while taking Xtandi amplifies its side effects and opens the door to other potential risks. Luckily, we can minimize these risks by quitting or cutting back on alcohol. Exact the full effectiveness of Xtandi by avoiding interactions!
Lisinopril is a common blood pressure medication that clashes with alcohol. Check out our latest blog for more info on the indirect interactions between the two.
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually, with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app through the App Store or Google Play today!
Adding a daily 30-minute walk, swapping out your morning donut for some heart-healthy egg bites, and myriad other tactics to lower your blood pressure just may not do the trick. After another check-up, your may prescribe lisinopril to manage your blood pressure. Now you’re wondering if the occasional glass of wine or bottle of beer fits into the equation.
Mixing medications with alcohol can be like playing with fire. Although the lisinopril label doesn’t clearly state alcohol as a drug interaction, drinking isn’t advised. Drinking while taking lisinopril can open the floodgates to many adverse effects. Let’s explore how alcohol and lisinopril interact to understand why rethinking the drink may be the best move for our health.
Lisinopril is one of the most commonly prescribed FDA-approved medications used to treat high blood pressure. However, it’s also used for many other purposes, including improving symptoms of heart failure, increasing survival rate after a heart attack, and lowering the risk of diabetes. It comes in tablet or solution form and is commonly sold under the brand name Zestril and Prinivil.
The drug is classified as an angiotensin-converting enzyme (ACE) inhibitor. It works by reducing chemicals that tighten our blood vessels. This allows for greater blood flow and, as a result, helps our heart pump more efficiently. Lisinopril is a common medication that can be effective in treating different health concerns, but how safe is it?
Lisinopril is regarded as generally safe, which is why it’s prescribed so frequently. No major adverse effects are associated with it. Although
withdrawal symptoms have been associated with some blood pressure medications but none have been reported with lisinopril. It may cause some mild side effects:
More severe side effects include:
Anyone experiencing any serious side effects after taking lisinopril should immediately stop taking the medication and dial 9-1-1 for emergency medical treatment. Although lisinopril is generally safe, it’s not appropriate for everyone. FDA warnings note that lisinopril shouldn’t be taken by
Lisinopril may be a safe and effective medication, but what about when it’s mixed with alcohol?
Drinking alcohol while taking lisinopril is not recommended. Although no direct interaction with alcohol is listed, mixing the two can cause serious adverse effects.
Alcohol indirectly affects lisinopril in many different ways. When we drink, alcohol can acutely lower our blood pressure — adding to the effects of the medication and increasing the risk of dangerously low blood pressure (hypotension). Over time, alcohol increases our blood pressure, which counteracts the purpose of the medication. This can lead to the ineffectiveness of the medication and other health conditions caused by high blood pressure.
Lisinopril is also used to improve other health issues such as heart failure, recurrence of heart attacks, and risk of diabetes. Drinking has negative impacts on these conditions. Alcohol can trigger atrial fibrillation, or irregular heart rhythm, which increases the risk of heart failure and heart attack. Drinking is also linked to an increased risk of diabetes and kidney damage — counteracting the medication when used for these purposes.
As we can see, although alcohol and lisinopril don’t have any direct interactions, their indirect interactions can be equally as harmful to our health. Lisinopril and alcohol aren’t a good mix, but what about other blood pressure medications?
Drinking while taking any blood pressure medication is not recommended. There are different types of blood pressure medications, including beta blockers, nondihydropyridine calcium channel blockers, angiotensin II blockers (ARBs), and many more that can cause negative effects when mixed with alcohol.
Beta-blockers, a common category of blood pressure medications, work by slowing down our heart rate. When mixed with alcohol, they can cause dangerous side effects such as tachycardia, excess drowsiness, and hypotension. Alcohol also directly interacts with nondihydropyridine calcium channel blockers such as Calan and Cartizem. This can lead to delayed alcohol metabolization — increasing the risk of alcohol poisoning. Other blood pressure medications, such as ARBs and Losartan, don’t interact directly with alcohol, but the combo can lead to increased side effects.
Drinking while taking some blood pressure medications may be more dangerous than others, but should generally be avoided to reduce complications and negative effects. Let’s get a better idea of what these are.
Alcohol can interact differently with different types of blood pressure medications. However, mixing them can lead to general adverse effects from indirect interactions, regardless of the type of blood pressure medication.
Drinking while taking blood pressure medications increases the risk of side effects, but does the amount of alcohol make a difference?
When taking lisinopril, no amount of alcohol is recommended. Although lisinopril interactions with alcohol aren’t direct, indirect interactions can still cause dangerous effects. According to the World Health Organization, no amount of alcohol is safe for our health.
If we do choose to drink, it’s best to consult with our physician, as they have a better idea of our health needs. Being honest with our healthcare provider helps us identify any interactions and helps us adjust our care as needed. Let’s explore some ways to increase our safety when taking lisinopril, drinking, and navigating the two.
If we’ve been prescribed lisinopril, we may feel overwhelmed with all this information. To ensure our health and safety, we can implement mindful consumption strategies:
The only way to eliminate negative effects from mixing alcohol and lisinopril is by avoiding alcohol, but we can reduce the risks using these mindful consumption strategies.
While we often attribute our high blood pressure to certain family members and stressful situations, hypertension can be caused by an interplay of many factors — making management a delicate dance of lifestyle changes and medication. If we’re taking lisinopril for blood pressure or its other uses, drinking alcohol isn’t a good idea. Although there aren’t any direct interactions, alcohol negatively affects our blood pressure and risk of heart issues, which lisinopril is used to treat. By choosing to limit or avoid alcohol, we can manage our hypertension better and take steps towards overall wellness. Cheers to a happy heart!
Adding a daily 30-minute walk, swapping out your morning donut for some heart-healthy egg bites, and myriad other tactics to lower your blood pressure just may not do the trick. After another check-up, your may prescribe lisinopril to manage your blood pressure. Now you’re wondering if the occasional glass of wine or bottle of beer fits into the equation.
Mixing medications with alcohol can be like playing with fire. Although the lisinopril label doesn’t clearly state alcohol as a drug interaction, drinking isn’t advised. Drinking while taking lisinopril can open the floodgates to many adverse effects. Let’s explore how alcohol and lisinopril interact to understand why rethinking the drink may be the best move for our health.
Lisinopril is one of the most commonly prescribed FDA-approved medications used to treat high blood pressure. However, it’s also used for many other purposes, including improving symptoms of heart failure, increasing survival rate after a heart attack, and lowering the risk of diabetes. It comes in tablet or solution form and is commonly sold under the brand name Zestril and Prinivil.
The drug is classified as an angiotensin-converting enzyme (ACE) inhibitor. It works by reducing chemicals that tighten our blood vessels. This allows for greater blood flow and, as a result, helps our heart pump more efficiently. Lisinopril is a common medication that can be effective in treating different health concerns, but how safe is it?
Lisinopril is regarded as generally safe, which is why it’s prescribed so frequently. No major adverse effects are associated with it. Although
withdrawal symptoms have been associated with some blood pressure medications but none have been reported with lisinopril. It may cause some mild side effects:
More severe side effects include:
Anyone experiencing any serious side effects after taking lisinopril should immediately stop taking the medication and dial 9-1-1 for emergency medical treatment. Although lisinopril is generally safe, it’s not appropriate for everyone. FDA warnings note that lisinopril shouldn’t be taken by
Lisinopril may be a safe and effective medication, but what about when it’s mixed with alcohol?
Drinking alcohol while taking lisinopril is not recommended. Although no direct interaction with alcohol is listed, mixing the two can cause serious adverse effects.
Alcohol indirectly affects lisinopril in many different ways. When we drink, alcohol can acutely lower our blood pressure — adding to the effects of the medication and increasing the risk of dangerously low blood pressure (hypotension). Over time, alcohol increases our blood pressure, which counteracts the purpose of the medication. This can lead to the ineffectiveness of the medication and other health conditions caused by high blood pressure.
Lisinopril is also used to improve other health issues such as heart failure, recurrence of heart attacks, and risk of diabetes. Drinking has negative impacts on these conditions. Alcohol can trigger atrial fibrillation, or irregular heart rhythm, which increases the risk of heart failure and heart attack. Drinking is also linked to an increased risk of diabetes and kidney damage — counteracting the medication when used for these purposes.
As we can see, although alcohol and lisinopril don’t have any direct interactions, their indirect interactions can be equally as harmful to our health. Lisinopril and alcohol aren’t a good mix, but what about other blood pressure medications?
Drinking while taking any blood pressure medication is not recommended. There are different types of blood pressure medications, including beta blockers, nondihydropyridine calcium channel blockers, angiotensin II blockers (ARBs), and many more that can cause negative effects when mixed with alcohol.
Beta-blockers, a common category of blood pressure medications, work by slowing down our heart rate. When mixed with alcohol, they can cause dangerous side effects such as tachycardia, excess drowsiness, and hypotension. Alcohol also directly interacts with nondihydropyridine calcium channel blockers such as Calan and Cartizem. This can lead to delayed alcohol metabolization — increasing the risk of alcohol poisoning. Other blood pressure medications, such as ARBs and Losartan, don’t interact directly with alcohol, but the combo can lead to increased side effects.
Drinking while taking some blood pressure medications may be more dangerous than others, but should generally be avoided to reduce complications and negative effects. Let’s get a better idea of what these are.
Alcohol can interact differently with different types of blood pressure medications. However, mixing them can lead to general adverse effects from indirect interactions, regardless of the type of blood pressure medication.
Drinking while taking blood pressure medications increases the risk of side effects, but does the amount of alcohol make a difference?
When taking lisinopril, no amount of alcohol is recommended. Although lisinopril interactions with alcohol aren’t direct, indirect interactions can still cause dangerous effects. According to the World Health Organization, no amount of alcohol is safe for our health.
If we do choose to drink, it’s best to consult with our physician, as they have a better idea of our health needs. Being honest with our healthcare provider helps us identify any interactions and helps us adjust our care as needed. Let’s explore some ways to increase our safety when taking lisinopril, drinking, and navigating the two.
If we’ve been prescribed lisinopril, we may feel overwhelmed with all this information. To ensure our health and safety, we can implement mindful consumption strategies:
The only way to eliminate negative effects from mixing alcohol and lisinopril is by avoiding alcohol, but we can reduce the risks using these mindful consumption strategies.
While we often attribute our high blood pressure to certain family members and stressful situations, hypertension can be caused by an interplay of many factors — making management a delicate dance of lifestyle changes and medication. If we’re taking lisinopril for blood pressure or its other uses, drinking alcohol isn’t a good idea. Although there aren’t any direct interactions, alcohol negatively affects our blood pressure and risk of heart issues, which lisinopril is used to treat. By choosing to limit or avoid alcohol, we can manage our hypertension better and take steps towards overall wellness. Cheers to a happy heart!
These days, there are plenty of options when it comes to medication to stop drinking, alcohol craving medication, and meds that help with withdrawal. Learn all about them in our latest blog!
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually, with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app through the App Store or Google Play today!
When we find ourselves in a tricky situation, it’s natural to wish for a magic pill to make it go away. And alcohol misuse is, certainly, a tricky situation (to say the least). It can feel nearly impossible to stop drinking once the habit takes hold, and you might find yourself wondering, “If only there were a pill to stop drinking!”
If you’re facing this problem, first of all, know that you’re not alone. And if you’re wondering how to stop alcohol cravings or if there’s a medication to stop drinking, you’re in luck — there are several! Let’s explore the pros and cons of each to help you decide if one is right for you, based on your needs and goals around alcohol.
First things first: what exactly are we dealing with? Alcohol use disorder (AUD) is a progressive mental health condition marked by an inability to stop excessive drinking. According to the National Institute on Alcohol Abuse and Alcoholism (NIAAA), in the U.S. as many as 29.5 million people ages 12 and older are struggling with AUD. That’s more than 10% of everyone in this age group!
While it might puzzle a nondrinker who has never dealt with alcoholism (“Why can’t they just stop?”), there’s brain chemistry behind the condition and its often devastating effects. For an in-depth look at AUD, check out our blog “What Is Alcohol Use Disorder?” For now, here’s the gist of it:
Needless to say, once we’re at the stage of dependence, getting out of the alcohol trap can seem all but impossible. But rest assured, there’s a way out!
This is where medications come in (at least for some of us). There are three main approaches to treating AUD with medications: making alcohol less effective, making it intolerable, or making it less desirable. Let’s explore each one in more detail.
Why is drinking so habit-forming to begin with? As we know, it’s all about brain chemistry. Let’s face it: without that dopamine rush, fewer people would probably be guzzling down a liquid that doesn’t always taste great on its own (there’s a reason it’s called an “acquired taste”).
Medications that interfere with the rewarding effects associated with drinking take out the pleasure factor, making it easier to stay away from booze. After all, with the main reason to drink out of the picture, what’s the point?
Naltrexone was originally developed to treat opioid addiction, but has been gaining traction as an effective treatment for AUD. Chemically similar to opioids but without the same euphoric effects, it works by blocking opioid receptors in the brain. Because these receptors are part of the brain’s reward system activated by alcohol, blocking them reduces the pleasure we get from drinking.
Imagine you’re waiting for a fun package (a chocolate wafer cake, a new yoga outfit — whatever tickles your fancy), but your mailbox is so full of junk mail that nothing else can fit. The postal worker ends up taking your package back to the post office and you’re left with a pile of mail that’s neither good nor bad — it’s just taking up space. Well, that’s what naltrexone does to our brain! (For a deep dive, check out “Unlocking the Science: How Long Does Naltrexone Block Alcohol?”)
Pros:
Cons:
A chemical counterpart of naltrexone, nalmefene is an opioid antagonist. Instead of acting as an opioid by binding to opioid receptors, it blocks the receptors completely — breaking the metaphorical mailbox lock and making it impossible to open at all. The result, however, is the same — we don’t get the reward associated with drinking.
Pros:
Cons:
A more drastic way to treat AUD with medications involves making booze highly unpleasant instead of merely neutral. Sure, this one’s not for the faint of heart (and is only right for those committed to leaving alcohol behind for good). Still, many have found that taking a medication that induces alcohol intolerance is actually an effective way to get back in the driver’s seat when it comes to making daily decisions. Took your meds in the morning? You know booze is out of the question tonight — no need for the time-consuming and exhausting mental back-and-forth throughout the day.
The story of disulfiram (known by the brand name Antabuse) began — of all places — in a rubber plant. At the turn of the 20th century, it was used in the industrial process of rubber production. A couple of decades later, some workers at a Swedish rubber boot factory (along with their American counterparts) noticed a curious trend: for those exposed to the chemical on a regular basis, “happy hour” wasn’t quite so happy anymore. When mixed with alcohol, disulfiram seemed to induce flushing, nausea, and palpitations — symptoms similar to those of alcohol intolerance.
While the workers at the rubber factory probably found this to be a buzzkill, the properties of disulfiram eventually proved to be useful in treating AUD. As it turned out, it throws a wrench in the metabolism of alcohol, leading to a build-up of a toxic by-product, acetaldehyde. While acetaldehyde is normally converted into harmless acetate by the liver, disulfiram makes it stick around, leading to symptoms that are (to put it mildly) highly unpleasant. (For more information, check out our blog “How Does Disulfiram Work?”.)
Pros:
Cons:
Similar in action to disulfiram, calcium carbimide also interferes with alcohol metabolism. If we drink on this medication, we’ll experience unpleasant effects that act as a deterrent to drinking.
Pros:
Cons:
Now, let’s step back a bit. We talked about why alcohol loses its “magic” if we’re taking naltrexone or nalmefene. But think about what happens before we drink, before we take disulfiram to ward off the temptation to pour it in the first place. The answer is, a thought — “I want a drink” — enters our head. That thought is often referred to as an urge or a craving — and many believe that it’s the very root of addiction.
What do cravings feel like? It depends on the person, but when it comes to substance use, cravings are desires for something we wish we didn’t want (now that’s mind-bending, isn’t it?). By eliminating the craving, which is the result of brain chemistry conditioned by habitual alcohol use, we eliminate the “need” we feel to have that drink.
It’s important to understand that cravings are not “true” desires, and that as far as habits are concerned, “wanting” isn’t the same as “liking.” Dopamine makes us feel like we want things we don’t necessarily enjoy — that’s why we can feel the compulsion to keep drinking in spite of the fact that alcohol isn’t providing authentic enjoyment. At a certain point, if we’ve become dependent, even the illusion of pleasure disappears, while the craving only seems to grow stronger.
Medications that target cravings, in turn, help us interrupt the vicious cycle from the get-go. The result? We don’t have to pour that drink, taste it, and find it unsatisfying. We don’t have to safeguard ourselves from having it by taking medications that could send us to the emergency room if we mix them with booze. In fact, alcohol might not even cross our mind at all!
For those who are committed to being booze-free, Campral has been a popular option. One important caveat: it works over time and is meant for those who’ve left alcohol behind and are trying to stay away from it for good.
Pros:
Cons:
Topiramate, in turn, targets cravings by decreasing the dopamine release associated with alcohol use. The result? Just like the first category of drugs, Topamax makes booze lose its appeal. However, because the effect is indirect (we’re talking about the reward system as opposed to opioid receptors), it affects our desire for alcohol and — like Campral — lives in the realm of cravings.
Pros:
Cons:
Gabapentin is beneficial for managing withdrawal symptoms and reducing alcohol cravings. Developed as an antiseizure medication, it helps stabilize the brain’s electrical activity and has been shown to be effective in treating alcohol dependence.
Pros:
Cons:
Now that we’re familiar with the meds out there that can help us stop drinking or reduce our cravings, what do we do with this information? Here are some questions to consider as you decide if any one of these treatments might be the right course for you.
First and foremost, the answer depends on your goals. Those who want to quit completely and are committed to staying booze-free will have different needs from those who simply want alcohol to be less prominent in their lives.
And remember what we said about decision fatigue? Science says we make about 35,000 decisions a day. Needless to say, our brain gets tired from the constant back-and-forth.
When we throw medications for AUD into the mix, the number of daily decisions is a factor to keep in mind. Remember, we’re talking about the decision to take the medication as well as the decision whether or not to drink.
Finally, overall health is also an important factor. All medications have side effects, and those that help with AUD recovery are no exception. Plus, some of us may have additional needs that we’re trying to address with medications.
Finally, it’s important to keep in mind that if it turns out medication isn’t the right route for you, there are plenty of ways to stop drinking without it! For a deep dive, check out “How Easy Is It To Quit Drinking in 2024?” For now, here are some tips to start with:
And remember, no matter which approach you choose, it’s essential to have a support system behind you. If you’re looking for a community of like-minded people who’ve been where you are and are now thriving, the Reframe forum is a great place to start!
When we find ourselves in a tricky situation, it’s natural to wish for a magic pill to make it go away. And alcohol misuse is, certainly, a tricky situation (to say the least). It can feel nearly impossible to stop drinking once the habit takes hold, and you might find yourself wondering, “If only there were a pill to stop drinking!”
If you’re facing this problem, first of all, know that you’re not alone. And if you’re wondering how to stop alcohol cravings or if there’s a medication to stop drinking, you’re in luck — there are several! Let’s explore the pros and cons of each to help you decide if one is right for you, based on your needs and goals around alcohol.
First things first: what exactly are we dealing with? Alcohol use disorder (AUD) is a progressive mental health condition marked by an inability to stop excessive drinking. According to the National Institute on Alcohol Abuse and Alcoholism (NIAAA), in the U.S. as many as 29.5 million people ages 12 and older are struggling with AUD. That’s more than 10% of everyone in this age group!
While it might puzzle a nondrinker who has never dealt with alcoholism (“Why can’t they just stop?”), there’s brain chemistry behind the condition and its often devastating effects. For an in-depth look at AUD, check out our blog “What Is Alcohol Use Disorder?” For now, here’s the gist of it:
Needless to say, once we’re at the stage of dependence, getting out of the alcohol trap can seem all but impossible. But rest assured, there’s a way out!
This is where medications come in (at least for some of us). There are three main approaches to treating AUD with medications: making alcohol less effective, making it intolerable, or making it less desirable. Let’s explore each one in more detail.
Why is drinking so habit-forming to begin with? As we know, it’s all about brain chemistry. Let’s face it: without that dopamine rush, fewer people would probably be guzzling down a liquid that doesn’t always taste great on its own (there’s a reason it’s called an “acquired taste”).
Medications that interfere with the rewarding effects associated with drinking take out the pleasure factor, making it easier to stay away from booze. After all, with the main reason to drink out of the picture, what’s the point?
Naltrexone was originally developed to treat opioid addiction, but has been gaining traction as an effective treatment for AUD. Chemically similar to opioids but without the same euphoric effects, it works by blocking opioid receptors in the brain. Because these receptors are part of the brain’s reward system activated by alcohol, blocking them reduces the pleasure we get from drinking.
Imagine you’re waiting for a fun package (a chocolate wafer cake, a new yoga outfit — whatever tickles your fancy), but your mailbox is so full of junk mail that nothing else can fit. The postal worker ends up taking your package back to the post office and you’re left with a pile of mail that’s neither good nor bad — it’s just taking up space. Well, that’s what naltrexone does to our brain! (For a deep dive, check out “Unlocking the Science: How Long Does Naltrexone Block Alcohol?”)
Pros:
Cons:
A chemical counterpart of naltrexone, nalmefene is an opioid antagonist. Instead of acting as an opioid by binding to opioid receptors, it blocks the receptors completely — breaking the metaphorical mailbox lock and making it impossible to open at all. The result, however, is the same — we don’t get the reward associated with drinking.
Pros:
Cons:
A more drastic way to treat AUD with medications involves making booze highly unpleasant instead of merely neutral. Sure, this one’s not for the faint of heart (and is only right for those committed to leaving alcohol behind for good). Still, many have found that taking a medication that induces alcohol intolerance is actually an effective way to get back in the driver’s seat when it comes to making daily decisions. Took your meds in the morning? You know booze is out of the question tonight — no need for the time-consuming and exhausting mental back-and-forth throughout the day.
The story of disulfiram (known by the brand name Antabuse) began — of all places — in a rubber plant. At the turn of the 20th century, it was used in the industrial process of rubber production. A couple of decades later, some workers at a Swedish rubber boot factory (along with their American counterparts) noticed a curious trend: for those exposed to the chemical on a regular basis, “happy hour” wasn’t quite so happy anymore. When mixed with alcohol, disulfiram seemed to induce flushing, nausea, and palpitations — symptoms similar to those of alcohol intolerance.
While the workers at the rubber factory probably found this to be a buzzkill, the properties of disulfiram eventually proved to be useful in treating AUD. As it turned out, it throws a wrench in the metabolism of alcohol, leading to a build-up of a toxic by-product, acetaldehyde. While acetaldehyde is normally converted into harmless acetate by the liver, disulfiram makes it stick around, leading to symptoms that are (to put it mildly) highly unpleasant. (For more information, check out our blog “How Does Disulfiram Work?”.)
Pros:
Cons:
Similar in action to disulfiram, calcium carbimide also interferes with alcohol metabolism. If we drink on this medication, we’ll experience unpleasant effects that act as a deterrent to drinking.
Pros:
Cons:
Now, let’s step back a bit. We talked about why alcohol loses its “magic” if we’re taking naltrexone or nalmefene. But think about what happens before we drink, before we take disulfiram to ward off the temptation to pour it in the first place. The answer is, a thought — “I want a drink” — enters our head. That thought is often referred to as an urge or a craving — and many believe that it’s the very root of addiction.
What do cravings feel like? It depends on the person, but when it comes to substance use, cravings are desires for something we wish we didn’t want (now that’s mind-bending, isn’t it?). By eliminating the craving, which is the result of brain chemistry conditioned by habitual alcohol use, we eliminate the “need” we feel to have that drink.
It’s important to understand that cravings are not “true” desires, and that as far as habits are concerned, “wanting” isn’t the same as “liking.” Dopamine makes us feel like we want things we don’t necessarily enjoy — that’s why we can feel the compulsion to keep drinking in spite of the fact that alcohol isn’t providing authentic enjoyment. At a certain point, if we’ve become dependent, even the illusion of pleasure disappears, while the craving only seems to grow stronger.
Medications that target cravings, in turn, help us interrupt the vicious cycle from the get-go. The result? We don’t have to pour that drink, taste it, and find it unsatisfying. We don’t have to safeguard ourselves from having it by taking medications that could send us to the emergency room if we mix them with booze. In fact, alcohol might not even cross our mind at all!
For those who are committed to being booze-free, Campral has been a popular option. One important caveat: it works over time and is meant for those who’ve left alcohol behind and are trying to stay away from it for good.
Pros:
Cons:
Topiramate, in turn, targets cravings by decreasing the dopamine release associated with alcohol use. The result? Just like the first category of drugs, Topamax makes booze lose its appeal. However, because the effect is indirect (we’re talking about the reward system as opposed to opioid receptors), it affects our desire for alcohol and — like Campral — lives in the realm of cravings.
Pros:
Cons:
Gabapentin is beneficial for managing withdrawal symptoms and reducing alcohol cravings. Developed as an antiseizure medication, it helps stabilize the brain’s electrical activity and has been shown to be effective in treating alcohol dependence.
Pros:
Cons:
Now that we’re familiar with the meds out there that can help us stop drinking or reduce our cravings, what do we do with this information? Here are some questions to consider as you decide if any one of these treatments might be the right course for you.
First and foremost, the answer depends on your goals. Those who want to quit completely and are committed to staying booze-free will have different needs from those who simply want alcohol to be less prominent in their lives.
And remember what we said about decision fatigue? Science says we make about 35,000 decisions a day. Needless to say, our brain gets tired from the constant back-and-forth.
When we throw medications for AUD into the mix, the number of daily decisions is a factor to keep in mind. Remember, we’re talking about the decision to take the medication as well as the decision whether or not to drink.
Finally, overall health is also an important factor. All medications have side effects, and those that help with AUD recovery are no exception. Plus, some of us may have additional needs that we’re trying to address with medications.
Finally, it’s important to keep in mind that if it turns out medication isn’t the right route for you, there are plenty of ways to stop drinking without it! For a deep dive, check out “How Easy Is It To Quit Drinking in 2024?” For now, here are some tips to start with:
And remember, no matter which approach you choose, it’s essential to have a support system behind you. If you’re looking for a community of like-minded people who’ve been where you are and are now thriving, the Reframe forum is a great place to start!
Wondering if Xanax and alcohol interactions could be dangerous? Learn why alcohol and Xanax don’t mix in our latest blog. Stay safe while getting relief for anxiety!
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app today!
Panic attacks can be debilitating, like a wave that swallows us whole as we try to find our bearings — and “words of encouragement” tend to make things even worse. As Elyn Saks writes in The Center Cannot Hold: My Journey Through Madness, “In my experience, the words “now just calm down” almost inevitably have the opposite effect on the person you are speaking to.”
While there are many ways to relieve anxiety (more on that later!), for many of us, medications such as Xanax can serve as lifelines. But what about interactions of Xanax and alcohol? In particular, you might be wondering, “If I take Xanax in the morning, can I drink alcohol at night?” The short answer is — not really. It’s best not to risk it. But what are the dangers, exactly? Let’s find out!
Anxiety — when it reaches the level of panic attacks and impacts our daily lives — can be debilitating. It can cause problems at work (especially if our job involves presentations in front of large groups of people, meetings with clients, and even regular huddles with coworkers). It can put a strain on relationships, making us hesitant to accept invitations to weddings or weekend outings. It can steal valuable hours of sleep at night as we toss and turn, unable to get our mind to settle no matter how many sheep we count in our head.
And yet, anxiety is extremely common. In fact, according to the National Institute of Mental Health, over 19% of U.S. adults struggle with it! That’s almost one in five people at that board meeting or at least a couple of members of the wedding party — or a total of about 40 million people around the country. As physician Will Cronenwett tells TODAY.com:
“We live in an unsettled time … There’s inflation. The war. Stuff in the news. And we’re still dealing with COVID and what that did to our baseline anxiety levels … People feel less safe, and feeling unsafe about yourself in the world is similar to the feeling of anxiety disorder.”
For many, medication becomes a lifeline, and benzodiazepines such as lorazepam (Ativan), clonazepam (Klonopin), diazepam (Valium), and alprazolam (Xanax) have historically been some of the most popular. That said, they have their drawbacks — in particular, their sedating side effects and potential for addiction, which we’ll get into a bit later.
Like its benzodiazepine cousins, alprazolam (better known by its brand name Xanax) is frequently prescribed for panic attacks and anxiety disorders. Patented in 1971, Xanax was invented by Jackson Hester Jr. and has been on the medical scene in the U.S. since 1981. In 2021, it ranked 42nd on the “most commonly prescribed medication” list, with more than 15 million prescriptions doled out to (presumably) anxiety sufferers around the country.
Benzodiazepines (affectionately known as “benzos”) work by enhancing the effects of GABA — an inhibitory neurotransmitter in the brain. If this rings a bell, there’s a good reason — alcohol works through a similar mechanism by enhancing GABA and decreasing glutamate, its excitatory counterpart.
As far as benzos are concerned, Xanax is a bit of a “bad boy.” It has stronger effects on some and acts within minutes, with effects lasting between four to six hours. Because it’s more fast-acting than its counterparts, it has more potential for addiction, as well as a heavier presence “on the street.” As Cronenwett explains, “It tends to act quickly and wear off fairly quickly. Often people feel they need to use it more and more frequently. And then the thought of living without it becomes frightening. In some cases, it can begin to look like addiction.” It can also cause severe withdrawal symptoms, such as seizures, especially in those taking a large dose.
There are many slang terms for Xanax in popular culture. Top of the list? “Xannies,” or “Zannies.” Additionally, Xanax is sometimes referred to as “bars,” “ladders,” “footballs,” “planks,” “poles,” “sticks,” “blues,” or “blue footballs.” (All describing the physical shape of the pills, if you haven’t guessed it already.)
A 2022 documentary, Take Your Pills: Xanax, looks deep into the “soul” of this somewhat controversial medicine, describing it as “a cure for some and a curse for others.” Regardless of the path we take when it comes to Xanax alone, however, there’s definite trouble on the horizon when it comes to Xanax and alcohol interactions.
Can you drink on Xanax? Most people know better than to chase a pill with a shot of tequila. But what if we take it in the morning — does it make that margarita or round of beers after work off limits? The truth is, we’re better off staying away from booze for at least 24 hours after taking Xanax. Let’s dive into the reasons why mixing alcohol and Xanax could mean trouble, even with a time gap in between.
Both Xanax and alcohol are depressants that slow down the central nervous system. When we take them together, the depressant effects get amplified and could put us in danger. Here’s why:
In short, mixing two depressants isn’t worth the risk. But that’s not the end of the story!
In addition to excessive sedation, there are other side effects of Xanax that could linger for hours after our dose. Many of them don’t mix with alcohol, so drinking on the same night could be a recipe for trouble.
As we can see, the side effects of Xanax and alcohol together aren’t worth the risk. We’re better off avoiding the combo, and waiting until evening to drink doesn’t necessarily mean we’re in the clear.
When it comes to treating anxiety, Xanax and alcohol are not on the same team (even though they might initially appear to be). While it’s common to think of alcohol as “relaxing,” any relief we feel is the depressant effect at play. However, as the brain attempts to rebalance itself after being flooded with the reward neurotransmitter dopamine and GABA, it releases dynorphin — a neurochemical that is part of our brain's natural way of dampening down the feel-good response. It's like putting on the brakes when things are getting too rowdy. The result? We end up feeling more anxious than we did before.
That flood of dopamine we’ve mentioned a few times? Research shows that Xanax in particular triggers a hefty dose of dopamine to be released in the striatum (part of the reward center of the brain). While all benzodiazepines do so to some degree, alprazolam stands out among the rest. As a result, combining the two substances leads to a more intense dopamine flood — and more potential for dependence, as our brain starts to expect it as the “new normal.”
In fact, Xanax alone should be treated with caution, as far as dependence is concerned. According to NIDA, overdoses on benzos skyrocketed in the last couple of decades, rising from 1,135 in 1999 to 11,537 in 2017. After a brief decline to 9,711 deaths in 2019, overdoses were on the rise again, climbing to 12,499 by 2021. And with more potential for dependence than its chemical cousins, Xanax in particular is responsible for a large chunk of those numbers.
The combination of Xanax and alcohol also increases our chances of having an overdose. With alcohol in our system, the concentration of Xanax in our bloodstream gets higher. As a result, effects (such as sedation) get more pronounced.
Remember how we said it’s best to wait at least 24 hours after taking Xanax before having a drink? That’s because it typically takes about 11.2 hours for half of our Xanax dose to metabolize and leave our body. And given that we’re better off waiting until most of it has left our system, a full day is the way to go.
That said, there are many additional factors at play when it comes to determining the exact timing of when it might be safe to drink after taking Xanax.
All in all, mixing benzos and alcohol is risky business. Most doctors advise against drinking on any benzodiazepines, as the combo can be unpredictable, potentially causing severe side effects and complications.
Finally, here are some tips for reducing anxiety while staying safe when it comes to the Xanax and alcohol combo.
With these tips, you’ll be able to manage your anxiety better. You might find that you’re not even craving that drink at night after all! And remember, Reframe is always here to help if you’re struggling and want support on your alcohol journey.
Panic attacks can be debilitating, like a wave that swallows us whole as we try to find our bearings — and “words of encouragement” tend to make things even worse. As Elyn Saks writes in The Center Cannot Hold: My Journey Through Madness, “In my experience, the words “now just calm down” almost inevitably have the opposite effect on the person you are speaking to.”
While there are many ways to relieve anxiety (more on that later!), for many of us, medications such as Xanax can serve as lifelines. But what about interactions of Xanax and alcohol? In particular, you might be wondering, “If I take Xanax in the morning, can I drink alcohol at night?” The short answer is — not really. It’s best not to risk it. But what are the dangers, exactly? Let’s find out!
Anxiety — when it reaches the level of panic attacks and impacts our daily lives — can be debilitating. It can cause problems at work (especially if our job involves presentations in front of large groups of people, meetings with clients, and even regular huddles with coworkers). It can put a strain on relationships, making us hesitant to accept invitations to weddings or weekend outings. It can steal valuable hours of sleep at night as we toss and turn, unable to get our mind to settle no matter how many sheep we count in our head.
And yet, anxiety is extremely common. In fact, according to the National Institute of Mental Health, over 19% of U.S. adults struggle with it! That’s almost one in five people at that board meeting or at least a couple of members of the wedding party — or a total of about 40 million people around the country. As physician Will Cronenwett tells TODAY.com:
“We live in an unsettled time … There’s inflation. The war. Stuff in the news. And we’re still dealing with COVID and what that did to our baseline anxiety levels … People feel less safe, and feeling unsafe about yourself in the world is similar to the feeling of anxiety disorder.”
For many, medication becomes a lifeline, and benzodiazepines such as lorazepam (Ativan), clonazepam (Klonopin), diazepam (Valium), and alprazolam (Xanax) have historically been some of the most popular. That said, they have their drawbacks — in particular, their sedating side effects and potential for addiction, which we’ll get into a bit later.
Like its benzodiazepine cousins, alprazolam (better known by its brand name Xanax) is frequently prescribed for panic attacks and anxiety disorders. Patented in 1971, Xanax was invented by Jackson Hester Jr. and has been on the medical scene in the U.S. since 1981. In 2021, it ranked 42nd on the “most commonly prescribed medication” list, with more than 15 million prescriptions doled out to (presumably) anxiety sufferers around the country.
Benzodiazepines (affectionately known as “benzos”) work by enhancing the effects of GABA — an inhibitory neurotransmitter in the brain. If this rings a bell, there’s a good reason — alcohol works through a similar mechanism by enhancing GABA and decreasing glutamate, its excitatory counterpart.
As far as benzos are concerned, Xanax is a bit of a “bad boy.” It has stronger effects on some and acts within minutes, with effects lasting between four to six hours. Because it’s more fast-acting than its counterparts, it has more potential for addiction, as well as a heavier presence “on the street.” As Cronenwett explains, “It tends to act quickly and wear off fairly quickly. Often people feel they need to use it more and more frequently. And then the thought of living without it becomes frightening. In some cases, it can begin to look like addiction.” It can also cause severe withdrawal symptoms, such as seizures, especially in those taking a large dose.
There are many slang terms for Xanax in popular culture. Top of the list? “Xannies,” or “Zannies.” Additionally, Xanax is sometimes referred to as “bars,” “ladders,” “footballs,” “planks,” “poles,” “sticks,” “blues,” or “blue footballs.” (All describing the physical shape of the pills, if you haven’t guessed it already.)
A 2022 documentary, Take Your Pills: Xanax, looks deep into the “soul” of this somewhat controversial medicine, describing it as “a cure for some and a curse for others.” Regardless of the path we take when it comes to Xanax alone, however, there’s definite trouble on the horizon when it comes to Xanax and alcohol interactions.
Can you drink on Xanax? Most people know better than to chase a pill with a shot of tequila. But what if we take it in the morning — does it make that margarita or round of beers after work off limits? The truth is, we’re better off staying away from booze for at least 24 hours after taking Xanax. Let’s dive into the reasons why mixing alcohol and Xanax could mean trouble, even with a time gap in between.
Both Xanax and alcohol are depressants that slow down the central nervous system. When we take them together, the depressant effects get amplified and could put us in danger. Here’s why:
In short, mixing two depressants isn’t worth the risk. But that’s not the end of the story!
In addition to excessive sedation, there are other side effects of Xanax that could linger for hours after our dose. Many of them don’t mix with alcohol, so drinking on the same night could be a recipe for trouble.
As we can see, the side effects of Xanax and alcohol together aren’t worth the risk. We’re better off avoiding the combo, and waiting until evening to drink doesn’t necessarily mean we’re in the clear.
When it comes to treating anxiety, Xanax and alcohol are not on the same team (even though they might initially appear to be). While it’s common to think of alcohol as “relaxing,” any relief we feel is the depressant effect at play. However, as the brain attempts to rebalance itself after being flooded with the reward neurotransmitter dopamine and GABA, it releases dynorphin — a neurochemical that is part of our brain's natural way of dampening down the feel-good response. It's like putting on the brakes when things are getting too rowdy. The result? We end up feeling more anxious than we did before.
That flood of dopamine we’ve mentioned a few times? Research shows that Xanax in particular triggers a hefty dose of dopamine to be released in the striatum (part of the reward center of the brain). While all benzodiazepines do so to some degree, alprazolam stands out among the rest. As a result, combining the two substances leads to a more intense dopamine flood — and more potential for dependence, as our brain starts to expect it as the “new normal.”
In fact, Xanax alone should be treated with caution, as far as dependence is concerned. According to NIDA, overdoses on benzos skyrocketed in the last couple of decades, rising from 1,135 in 1999 to 11,537 in 2017. After a brief decline to 9,711 deaths in 2019, overdoses were on the rise again, climbing to 12,499 by 2021. And with more potential for dependence than its chemical cousins, Xanax in particular is responsible for a large chunk of those numbers.
The combination of Xanax and alcohol also increases our chances of having an overdose. With alcohol in our system, the concentration of Xanax in our bloodstream gets higher. As a result, effects (such as sedation) get more pronounced.
Remember how we said it’s best to wait at least 24 hours after taking Xanax before having a drink? That’s because it typically takes about 11.2 hours for half of our Xanax dose to metabolize and leave our body. And given that we’re better off waiting until most of it has left our system, a full day is the way to go.
That said, there are many additional factors at play when it comes to determining the exact timing of when it might be safe to drink after taking Xanax.
All in all, mixing benzos and alcohol is risky business. Most doctors advise against drinking on any benzodiazepines, as the combo can be unpredictable, potentially causing severe side effects and complications.
Finally, here are some tips for reducing anxiety while staying safe when it comes to the Xanax and alcohol combo.
With these tips, you’ll be able to manage your anxiety better. You might find that you’re not even craving that drink at night after all! And remember, Reframe is always here to help if you’re struggling and want support on your alcohol journey.
Tums doesn’t interact with alcohol but together they can still be trouble. Check out our latest blog for more info on why mixing Tums with alcohol is not a good idea.
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app today!
“Whenever heartburn strikes, get fast relief with Tums,” a big voice booms in a Tums TV spot as a woman rushes across an airport terminal to fling her arms around ... a gigantic fried chicken nuggets-chili peppers-and onion wrap. “It’s time to Love Food Back!”
But will Tums let you “Love Booze Back”?
Since Tums can aid GI discomfort, many a wishful thinker would like to believe this heartburn remedy can relieve their misery following a lively night at the local bar. But no genie can fulfill that wish for the simple reason that alcohol works against Tums! Let’s learn why.
An over-the-counter (OTC) medication, Tums is used to treat indigestion, upset stomach, and heartburn. The active ingredient in Tums is calcium carbonate, which is a basic compound that works by neutralizing excess stomach acid. Excess stomach acid can cause GI discomfort such as nausea, pain, bloating, and heartburn. Tums is most commonly used as an antacid, but, as a mined calcium supplement, it’s also used to treat conditions such as hypocalcemia, gastroesophageal reflux disease (GERD), chronic kidney disease, and preeclampsia.
The medication is associated with a few common but not serious side effects.
Antacids like Tums are meant to relieve uncomfortable symptoms, but they may not address the root cause. Tums is effective for the tummy, but does it still work if we have a drink or two?
Tums and alcohol don’t have any known interactions. However, Tums and alcohol still have indirect interactions that can lead to adverse effects. Both substances pass through our GI system, which can impact absorption and metabolism and lead to negative effects.
Tums and alcohol don’t interact directly. However, they still have many potential indirect interactions that have negative consequences. If we’ve already had a drink, is it a good idea to take Tums?
There are no immediate dangers or direct interactions between alcohol and Tums. However, if we need to take Tums after drinking, we may be ignoring the bigger issue at hand.
Alcohol can promote increased stomach acid production. This can irritate the lining of the stomach and cause inflammation. Inflammation of the stomach can cause GI symptoms such as bloating, pain, and nausea. Excess gastric acid can also increase the risk of acid traveling up into our esophagus, which causes heartburn. Over time, alcohol can cause permanent damage to our GI system, which leads to long-term health conditions.
Taking Tums after drinking may temporarily relieve some GI discomfort. However, even though Tums may mitigate some uncomfortable symptoms, alcohol continues to damage our cells and tissues within our digestive tract, which can lead to long-term damage and GI conditions. It’s similar to using a band-aid to cover a wound that needs stitches. Taking Tums after drinking can provide a false sense that alcohol isn’t wreaking havoc on our GI system just because we may not be feeling discomfort at the moment.
If we’re trying to prevent GI discomfort, there is no set amount of alcohol that is confirmed not to cause any adverse effects. We’re all different and may respond differently to alcohol. Any amount of alcohol can disrupt our GI function, as alcohol passes through our digestive tract.
If we have additional risk factors, we may be more susceptible to GI distress from alcohol. Prolonged and excessive drinking can also have permanent effects on our gut microbiome. For this reason, excessive drinking is associated with conditions such as irritable bowel syndrome (IBS) and GERD.
No exact amount of alcohol is recommended when trying to prevent negative health effects. However, if we’re choosing to drink, it's best to follow moderate consumption guidelines to minimize any risks.
Since there are no direct interactions between alcohol and Tums, there is no specific time frame after taking Tums that makes alcohol safer to drink. If we’re taking Tums for GI discomfort or associated conditions unrelated to alcohol, drinking can negatively affect us no matter when we consume alcohol.
The half-life of Tums ranges from 6 to 9 hours. That means half of the medication is eliminated in that period. Therefore, it’s best to wait at least 18 hours after taking Tums to drink alcohol. While there aren’t any adverse effects from mixing the two, waiting to drink ensures that our GI discomfort isn’t being masked by the medication.
GI symptoms that Tums is used to relieve often can be recurring and caused by underlying conditions. Drinking alcohol while taking Tums and after the medication is eliminated may exacerbate symptoms and create greater complications and discomfort. If we experience regular GI discomfort, it may be best to avoid alcohol (with or without Tums in the equation). Tums doesn’t directly interact with alcohol, but what about other antacids?
Although other antacids may work like Tums, they may have different active ingredients that can negatively interact with alcohol. Since antacids relieve symptoms of GI discomfort, they’re often perceived to be solutions for side effects of drinking. However, antacids and alcohol aren’t always a good mix. Let’s take a look at how alcohol interacts with other common antacids.
Pepto-Bismol is another OTC medication used to treat diarrhea, heartburn, indigestion, and upset stomach. The active ingredient in Pepto-Bismol is bismuth subsalicylate, which has anti-inflammatory properties that reduce gastric irritation and diarrhea.
The medication works by coating the stomach lining, which acts as a barrier between our stomach and irritating substances. It also has antimicrobial effects — making it commonly prescribed for GI infections such as H. pylori.
Although Pepto-Bismol is used to treat symptoms similar to those Tums addresses, Pepto works differently and increases the risk of GI bleeding. Pepto-Bismol and alcohol are both metabolized by our liver, which can prioritize breaking down one toxic substance at a time.
Pepcid is a medication used to treat conditions caused by excess stomach acid and to prevent stomach ulcers. The medication is categorized as an H2 antagonist. H2 blockers bind to our histamine receptors and suppress the production of stomach acid-reducing histamine actions.
There are minimally reported interactions between alcohol and Pepcid. However, some studies have found that the medication may slightly increase the absorption of alcohol — increasing our blood alcohol concentration (BAC).
Despite the potential dangers, Pepcid and alcohol are often combined to reduce symptoms of alcohol flush. As an H2 blocker, Pepcid may reduce alcohol intolerance symptoms by suppressing histamine function. But, because Pepcid may reduce these important warning signs, it may open the door to more long-term effects of alcohol.
Alka-Seltzer Original is a combination of citric acid, aspirin, and sodium bicarbonate. The medication is used to treat GI symptoms that are accompanied by headaches or body aches.
There are many different forms of Alka-Seltzer, including an antacid variation, which is composed of anhydrous citric acid and sodium bicarbonate. Since the different types of Alka-Seltzer have different active ingredients, it’s important to check the medication for specific interactions with alcohol.
Alcohol directly interacts with aspirin, which is found in the Original form of Alka-Seltzer. It also can interact indirectly with sodium bicarbonate and lead to adverse effects. Drinking while taking Alka-Seltzer, no matter the type, isn’t recommended as it can increase the risk of complications and negative side effects.
Whichever antacid we may be taking, individual factors may make combining antacids with alcohol more dangerous. What are some risk factors to keep in mind?
Although Tums and alcohol don’t interact directly, their indirect interactions can still be harmful. On top of that, individual factors may make mixing the two more dangerous for us in comparison to others. Certain considerations can help us rethink the drink when taking Tums.
Generally speaking, Tums and alcohol aren’t a dangerous duo. However, individual risk factors and alcohol’s indirect effects on the symptoms Tums is used to treat can still cause adverse effects. How can we prevent or limit these effects?
Heartburn and other GI symptoms caused by excess stomach acid can be extremely uncomfortable. Tums can aid in relieving symptoms, but addressing the root causes may require a more comprehensive approach.
Antacids like Tums can manage heartburn and GI symptoms in the short term. However, other strategies may be needed to address long-term issues. Quitting or cutting back on alcohol helps limit exacerbating symptoms.
Tums is an antacid for treating conditions related to excess gastric acid and several other conditions. Although Tums and alcohol don’t have any direct interactions, drinking can still lead to negative health effects. Alcohol can exacerbate symptoms that Tums is used to treat and damage our digestive system in the long term. Antacids like Tums are sometimes used to relieve unpleasant symptoms of drinking. However, they can mask the detrimental effects of alcohol — leading to increased risk of health conditions.
“Whenever heartburn strikes, get fast relief with Tums,” a big voice booms in a Tums TV spot as a woman rushes across an airport terminal to fling her arms around ... a gigantic fried chicken nuggets-chili peppers-and onion wrap. “It’s time to Love Food Back!”
But will Tums let you “Love Booze Back”?
Since Tums can aid GI discomfort, many a wishful thinker would like to believe this heartburn remedy can relieve their misery following a lively night at the local bar. But no genie can fulfill that wish for the simple reason that alcohol works against Tums! Let’s learn why.
An over-the-counter (OTC) medication, Tums is used to treat indigestion, upset stomach, and heartburn. The active ingredient in Tums is calcium carbonate, which is a basic compound that works by neutralizing excess stomach acid. Excess stomach acid can cause GI discomfort such as nausea, pain, bloating, and heartburn. Tums is most commonly used as an antacid, but, as a mined calcium supplement, it’s also used to treat conditions such as hypocalcemia, gastroesophageal reflux disease (GERD), chronic kidney disease, and preeclampsia.
The medication is associated with a few common but not serious side effects.
Antacids like Tums are meant to relieve uncomfortable symptoms, but they may not address the root cause. Tums is effective for the tummy, but does it still work if we have a drink or two?
Tums and alcohol don’t have any known interactions. However, Tums and alcohol still have indirect interactions that can lead to adverse effects. Both substances pass through our GI system, which can impact absorption and metabolism and lead to negative effects.
Tums and alcohol don’t interact directly. However, they still have many potential indirect interactions that have negative consequences. If we’ve already had a drink, is it a good idea to take Tums?
There are no immediate dangers or direct interactions between alcohol and Tums. However, if we need to take Tums after drinking, we may be ignoring the bigger issue at hand.
Alcohol can promote increased stomach acid production. This can irritate the lining of the stomach and cause inflammation. Inflammation of the stomach can cause GI symptoms such as bloating, pain, and nausea. Excess gastric acid can also increase the risk of acid traveling up into our esophagus, which causes heartburn. Over time, alcohol can cause permanent damage to our GI system, which leads to long-term health conditions.
Taking Tums after drinking may temporarily relieve some GI discomfort. However, even though Tums may mitigate some uncomfortable symptoms, alcohol continues to damage our cells and tissues within our digestive tract, which can lead to long-term damage and GI conditions. It’s similar to using a band-aid to cover a wound that needs stitches. Taking Tums after drinking can provide a false sense that alcohol isn’t wreaking havoc on our GI system just because we may not be feeling discomfort at the moment.
If we’re trying to prevent GI discomfort, there is no set amount of alcohol that is confirmed not to cause any adverse effects. We’re all different and may respond differently to alcohol. Any amount of alcohol can disrupt our GI function, as alcohol passes through our digestive tract.
If we have additional risk factors, we may be more susceptible to GI distress from alcohol. Prolonged and excessive drinking can also have permanent effects on our gut microbiome. For this reason, excessive drinking is associated with conditions such as irritable bowel syndrome (IBS) and GERD.
No exact amount of alcohol is recommended when trying to prevent negative health effects. However, if we’re choosing to drink, it's best to follow moderate consumption guidelines to minimize any risks.
Since there are no direct interactions between alcohol and Tums, there is no specific time frame after taking Tums that makes alcohol safer to drink. If we’re taking Tums for GI discomfort or associated conditions unrelated to alcohol, drinking can negatively affect us no matter when we consume alcohol.
The half-life of Tums ranges from 6 to 9 hours. That means half of the medication is eliminated in that period. Therefore, it’s best to wait at least 18 hours after taking Tums to drink alcohol. While there aren’t any adverse effects from mixing the two, waiting to drink ensures that our GI discomfort isn’t being masked by the medication.
GI symptoms that Tums is used to relieve often can be recurring and caused by underlying conditions. Drinking alcohol while taking Tums and after the medication is eliminated may exacerbate symptoms and create greater complications and discomfort. If we experience regular GI discomfort, it may be best to avoid alcohol (with or without Tums in the equation). Tums doesn’t directly interact with alcohol, but what about other antacids?
Although other antacids may work like Tums, they may have different active ingredients that can negatively interact with alcohol. Since antacids relieve symptoms of GI discomfort, they’re often perceived to be solutions for side effects of drinking. However, antacids and alcohol aren’t always a good mix. Let’s take a look at how alcohol interacts with other common antacids.
Pepto-Bismol is another OTC medication used to treat diarrhea, heartburn, indigestion, and upset stomach. The active ingredient in Pepto-Bismol is bismuth subsalicylate, which has anti-inflammatory properties that reduce gastric irritation and diarrhea.
The medication works by coating the stomach lining, which acts as a barrier between our stomach and irritating substances. It also has antimicrobial effects — making it commonly prescribed for GI infections such as H. pylori.
Although Pepto-Bismol is used to treat symptoms similar to those Tums addresses, Pepto works differently and increases the risk of GI bleeding. Pepto-Bismol and alcohol are both metabolized by our liver, which can prioritize breaking down one toxic substance at a time.
Pepcid is a medication used to treat conditions caused by excess stomach acid and to prevent stomach ulcers. The medication is categorized as an H2 antagonist. H2 blockers bind to our histamine receptors and suppress the production of stomach acid-reducing histamine actions.
There are minimally reported interactions between alcohol and Pepcid. However, some studies have found that the medication may slightly increase the absorption of alcohol — increasing our blood alcohol concentration (BAC).
Despite the potential dangers, Pepcid and alcohol are often combined to reduce symptoms of alcohol flush. As an H2 blocker, Pepcid may reduce alcohol intolerance symptoms by suppressing histamine function. But, because Pepcid may reduce these important warning signs, it may open the door to more long-term effects of alcohol.
Alka-Seltzer Original is a combination of citric acid, aspirin, and sodium bicarbonate. The medication is used to treat GI symptoms that are accompanied by headaches or body aches.
There are many different forms of Alka-Seltzer, including an antacid variation, which is composed of anhydrous citric acid and sodium bicarbonate. Since the different types of Alka-Seltzer have different active ingredients, it’s important to check the medication for specific interactions with alcohol.
Alcohol directly interacts with aspirin, which is found in the Original form of Alka-Seltzer. It also can interact indirectly with sodium bicarbonate and lead to adverse effects. Drinking while taking Alka-Seltzer, no matter the type, isn’t recommended as it can increase the risk of complications and negative side effects.
Whichever antacid we may be taking, individual factors may make combining antacids with alcohol more dangerous. What are some risk factors to keep in mind?
Although Tums and alcohol don’t interact directly, their indirect interactions can still be harmful. On top of that, individual factors may make mixing the two more dangerous for us in comparison to others. Certain considerations can help us rethink the drink when taking Tums.
Generally speaking, Tums and alcohol aren’t a dangerous duo. However, individual risk factors and alcohol’s indirect effects on the symptoms Tums is used to treat can still cause adverse effects. How can we prevent or limit these effects?
Heartburn and other GI symptoms caused by excess stomach acid can be extremely uncomfortable. Tums can aid in relieving symptoms, but addressing the root causes may require a more comprehensive approach.
Antacids like Tums can manage heartburn and GI symptoms in the short term. However, other strategies may be needed to address long-term issues. Quitting or cutting back on alcohol helps limit exacerbating symptoms.
Tums is an antacid for treating conditions related to excess gastric acid and several other conditions. Although Tums and alcohol don’t have any direct interactions, drinking can still lead to negative health effects. Alcohol can exacerbate symptoms that Tums is used to treat and damage our digestive system in the long term. Antacids like Tums are sometimes used to relieve unpleasant symptoms of drinking. However, they can mask the detrimental effects of alcohol — leading to increased risk of health conditions.
Explore the efficacy and considerations of using phenobarbital in medication-assisted treatment for alcohol withdrawal, including its mechanism, benefits, and potential risks.
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app through the App Store or Google Play today!
Alcohol withdrawal can be a severe and potentially life-threatening condition for individuals with chronic alcohol use disorder. Medication-assisted treatment (MAT) is a critical component in managing withdrawal symptoms and ensuring patient safety. Among the medications used, phenobarbital has garnered attention for its efficacy in treating alcohol withdrawal. This article explores the role of phenobarbital in MAT, its effectiveness, and important considerations for its use.
When a person with a history of heavy alcohol use suddenly stops drinking, their body can experience a range of withdrawal symptoms. These symptoms can vary from mild to severe and may include:
Severe withdrawal symptoms, particularly seizures and delirium tremens, can be life-threatening and require immediate medical intervention.
Phenobarbital is a barbiturate that has been used for decades to manage seizures and sedate patients. Its application in alcohol withdrawal treatment is based on its ability to enhance the inhibitory effects of gamma-aminobutyric acid (GABA) in the brain, which helps to counteract the hyperexcitability caused by alcohol withdrawal.
Phenobarbital works by increasing the activity of GABA, a neurotransmitter that inhibits nerve transmission in the brain, leading to a calming effect. During alcohol withdrawal, the brain is in a hyperexcitable state due to the sudden absence of alcohol, which previously enhanced GABA activity. By enhancing GABA activity, phenobarbital helps to stabilize the nervous system and reduce withdrawal symptoms.
Several studies have demonstrated the effectiveness of phenobarbital in managing alcohol withdrawal symptoms. It is particularly useful in preventing seizures and managing severe withdrawal symptoms such as delirium tremens. Phenobarbital's long half-life allows for less frequent dosing compared to other medications, which can improve patient compliance and reduce the risk of rebound symptoms.
A study conducted at a psychiatric hospital compared the use of phenobarbital to benzodiazepines for alcohol withdrawal management. The results indicated that phenobarbital was effective in reducing withdrawal symptoms and preventing seizures, with a similar safety profile to benzodiazepines.
Another study focused on outpatient treatment found that phenobarbital was effective in reducing withdrawal symptoms and preventing complications in patients with mild to moderate withdrawal. The study concluded that phenobarbital could be a viable alternative to benzodiazepines, particularly in settings where benzodiazepine use is contraindicated.
Phenobarbital dosage must be carefully titrated based on the severity of withdrawal symptoms and the patient's medical history. It is typically administered in a hospital or clinical setting where patients can be closely monitored. The initial dose is usually higher to rapidly control symptoms, followed by tapering doses to prevent rebound withdrawal.
While phenobarbital is effective, it is not without risks. Common side effects include drowsiness, dizziness, and ataxia. More severe side effects can include respiratory depression, especially when used in high doses or in combination with other sedatives. Therefore, it is crucial to monitor patients for signs of respiratory distress and other adverse effects.
Phenobarbital should be used with caution in patients with a history of substance abuse, respiratory disorders, or liver disease. It is also contraindicated in patients with a history of hypersensitivity to barbiturates. Due to its potential for dependence and abuse, phenobarbital should be prescribed and monitored by healthcare professionals experienced in managing alcohol withdrawal.
While phenobarbital is an effective option, it is not the only medication used for alcohol withdrawal. Benzodiazepines, such as diazepam and lorazepam, are commonly used and have a well-established safety profile. However, benzodiazepines carry a risk of dependence and may not be suitable for all patients.
Gabapentin, an anticonvulsant, has also been explored as a treatment for alcohol withdrawal. Studies have shown that gabapentin can be effective in reducing withdrawal symptoms, particularly in outpatient settings. It has a lower risk of dependence compared to benzodiazepines and phenobarbital, making it a suitable option for some patients. For more information, you can read about Gabapentin for Alcohol Withdrawal.
Phenobarbital plays a significant role in the medication-assisted treatment of alcohol withdrawal, particularly for managing severe symptoms and preventing seizures. Its efficacy, coupled with its long half-life, makes it a valuable option for both inpatient and outpatient settings. However, careful consideration must be given to its dosage, potential side effects, and patient-specific factors to ensure safe and effective treatment.
For individuals seeking to build healthier drinking habits and reframe their relationship with alcohol, understanding the options available for managing withdrawal is crucial. If you or a loved one is struggling with alcohol withdrawal, it is essential to seek professional medical advice to determine the most appropriate treatment plan.
Alcohol withdrawal can be a severe and potentially life-threatening condition for individuals with chronic alcohol use disorder. Medication-assisted treatment (MAT) is a critical component in managing withdrawal symptoms and ensuring patient safety. Among the medications used, phenobarbital has garnered attention for its efficacy in treating alcohol withdrawal. This article explores the role of phenobarbital in MAT, its effectiveness, and important considerations for its use.
When a person with a history of heavy alcohol use suddenly stops drinking, their body can experience a range of withdrawal symptoms. These symptoms can vary from mild to severe and may include:
Severe withdrawal symptoms, particularly seizures and delirium tremens, can be life-threatening and require immediate medical intervention.
Phenobarbital is a barbiturate that has been used for decades to manage seizures and sedate patients. Its application in alcohol withdrawal treatment is based on its ability to enhance the inhibitory effects of gamma-aminobutyric acid (GABA) in the brain, which helps to counteract the hyperexcitability caused by alcohol withdrawal.
Phenobarbital works by increasing the activity of GABA, a neurotransmitter that inhibits nerve transmission in the brain, leading to a calming effect. During alcohol withdrawal, the brain is in a hyperexcitable state due to the sudden absence of alcohol, which previously enhanced GABA activity. By enhancing GABA activity, phenobarbital helps to stabilize the nervous system and reduce withdrawal symptoms.
Several studies have demonstrated the effectiveness of phenobarbital in managing alcohol withdrawal symptoms. It is particularly useful in preventing seizures and managing severe withdrawal symptoms such as delirium tremens. Phenobarbital's long half-life allows for less frequent dosing compared to other medications, which can improve patient compliance and reduce the risk of rebound symptoms.
A study conducted at a psychiatric hospital compared the use of phenobarbital to benzodiazepines for alcohol withdrawal management. The results indicated that phenobarbital was effective in reducing withdrawal symptoms and preventing seizures, with a similar safety profile to benzodiazepines.
Another study focused on outpatient treatment found that phenobarbital was effective in reducing withdrawal symptoms and preventing complications in patients with mild to moderate withdrawal. The study concluded that phenobarbital could be a viable alternative to benzodiazepines, particularly in settings where benzodiazepine use is contraindicated.
Phenobarbital dosage must be carefully titrated based on the severity of withdrawal symptoms and the patient's medical history. It is typically administered in a hospital or clinical setting where patients can be closely monitored. The initial dose is usually higher to rapidly control symptoms, followed by tapering doses to prevent rebound withdrawal.
While phenobarbital is effective, it is not without risks. Common side effects include drowsiness, dizziness, and ataxia. More severe side effects can include respiratory depression, especially when used in high doses or in combination with other sedatives. Therefore, it is crucial to monitor patients for signs of respiratory distress and other adverse effects.
Phenobarbital should be used with caution in patients with a history of substance abuse, respiratory disorders, or liver disease. It is also contraindicated in patients with a history of hypersensitivity to barbiturates. Due to its potential for dependence and abuse, phenobarbital should be prescribed and monitored by healthcare professionals experienced in managing alcohol withdrawal.
While phenobarbital is an effective option, it is not the only medication used for alcohol withdrawal. Benzodiazepines, such as diazepam and lorazepam, are commonly used and have a well-established safety profile. However, benzodiazepines carry a risk of dependence and may not be suitable for all patients.
Gabapentin, an anticonvulsant, has also been explored as a treatment for alcohol withdrawal. Studies have shown that gabapentin can be effective in reducing withdrawal symptoms, particularly in outpatient settings. It has a lower risk of dependence compared to benzodiazepines and phenobarbital, making it a suitable option for some patients. For more information, you can read about Gabapentin for Alcohol Withdrawal.
Phenobarbital plays a significant role in the medication-assisted treatment of alcohol withdrawal, particularly for managing severe symptoms and preventing seizures. Its efficacy, coupled with its long half-life, makes it a valuable option for both inpatient and outpatient settings. However, careful consideration must be given to its dosage, potential side effects, and patient-specific factors to ensure safe and effective treatment.
For individuals seeking to build healthier drinking habits and reframe their relationship with alcohol, understanding the options available for managing withdrawal is crucial. If you or a loved one is struggling with alcohol withdrawal, it is essential to seek professional medical advice to determine the most appropriate treatment plan.
Have you heard that drinking while on lithium is strongly discouraged? Check out our latest blog to learn more about the dangerous effects of mixing alcohol and lithium.
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app today!
After reading the pamphlet with the paragraphs of tiny text that the pharmacist handed you with your lithium prescription, you may still be scratching your head. While the warnings do advise against drinking alcohol, they’re not exactly clear. Can you still drink alcohol while taking lithium?
Let’s take a closer look at the interactions between alcohol and lithium.
Lithium compounds such as lithium carbonate and lithium citrate are approved by the Federal Drug Administration (FDA) as prescription medications to treat bipolar disorder and other mood disorders. They act as mood stabilizers, which can help regulate changes between high mood (mania) and low mood (depression).
While most commonly used to treat bipolar disorder, lithium also hasbeen used off-label for neutropenia, depression, vascular headaches, Huntington’s disease, and more.
Despite its various uses, all forms of lithium are known for their delayed initial onset. According to the National Health Service (NHS), lithium can take anywhere from a week to months to take effect when it is taken initially.
Once lithium takes effect, its half-life ranges from 18-36 hours, implying that a single dose can stay in our system for up to 72 hours. However, we don’t see the peak effects of lithium until about five hours after ingestion, depending on the form and dosage. To maintain consistent efficacy throughout the day, doctors prescribe lithium to be taken at regular intervals.
This means that our first dose will still be lingering in our system when it’s time to take the second dose, which is why it’s difficult to pinpoint exactly how long it takes our body to eliminate lithium. It may take a week or more to be eliminated. So, is it okay to drink after a week of not taking lithium?
Before we’re able to determine if we can drink during and after taking lithium, let’s first understand how alcohol can interfere with our mood, which lithium is commonly prescribed to help regulate.
Alcohol affects our mood through chemical messengers in our brain known as neurotransmitters. Serotonin and dopamine are two of the main neurotransmitters that affect our mood.
After drinking, as our body metabolizes and eliminates alcohol, our serotonin and dopamine levels dip, causing more drastic fluctuations in our mood.
Over time, excessive and prolonged drinking can lead to permanent changes in our brain chemistry. Our brain will produce less serotonin and dopamine, which can prolong periods of low mood. Long-term alcohol use is also connected to impairments in our hypothalamic-pituitary-adrenal (HPA) axis, which can decrease our stress tolerance — increasing the risk of more drastic fluctuations in our mood.
These changes in our brain chemistry explain why long-term drinking is associated with mental health conditions such as anxiety, depression, and more. Alcohol and lithium both impact our mood, but how do they interact with each other?
Alcohol interacts with many drugs, including lithium. To determine if we can drink alcohol while taking lithium, let’s better understand the direct interactions between the two.
Alcohol and lithium interact in many different ways, so is it still okay to drink?
Drinking alcohol while taking lithium can be extremely dangerous. This is largely because lithium has a narrow therapeutic index, meaning there’s a small window between an effective dose and a toxic dose of lithium. Even subtle changes in fluid levels caused by drinking alcohol can lead to lithium toxicity — a life-threatening condition.
A study reviewing patients who were admitted to a psychiatric hospital found that 6.8% of patients being administered lithium had toxic levels of lithium at some point during their treatment. This is without any alcohol and in a highly controlled hospital setting. Adding alcohol into the equation (even one drink) can greatly increase the risk of lithium toxicity or other adverse effects.
But what if it’s just one drink? Since alcohol affects each of us differently, it’s difficult to determine a safe amount of alcohol that can be consumed without experiencing any negative effects. It’s best to avoid drinking altogether. Let’s take a closer look at the associated risks.
When alcohol interacts with lithium, our body can experience varying adverse effects. There are four direct consequences of drinking while taking lithium.
While taking lithium, alcohol can lead to many complications, but what about after discontinuing the medication?
The dangers of drinking after discontinuing lithium are less clear than while taking the medication. However, due to alcohol’s negative effects on our mood, it’s not advisable to drink even after discontinuing lithium.
If we choose to drink, it’s best to first consult with a physician. After discontinuing lithium, it may take some time before it’s completely eliminated from our system — making us susceptible to lithium toxicity. Depending on individual circumstances, other medications may also be prescribed — opening the door to other drug interactions. Drinking after taking lithium and while on the medication is not recommended, so how should we go about it?
Lithium and alcohol go together like oil and water. However, with alcohol being such a large aspect of our social culture, we may be faced with the choice of whether or not we should drink when taking lithium. If the situation does arise, there are ways we can prioritize our health and safety.
By following these tips, we can navigate lithium and alcohol consumption safely.
Warning labels on lithium medication may not be entirely clear on whether or not drinking is okay while taking these medications. However, a closer look at the interaction between lithium and alcohol reveals that drinking while taking lithium can lead to serious adverse effects — even in minimal amounts. Fortunately, healthy alternatives and support when needed can help us approach lithium and alcohol safely.
After reading the pamphlet with the paragraphs of tiny text that the pharmacist handed you with your lithium prescription, you may still be scratching your head. While the warnings do advise against drinking alcohol, they’re not exactly clear. Can you still drink alcohol while taking lithium?
Let’s take a closer look at the interactions between alcohol and lithium.
Lithium compounds such as lithium carbonate and lithium citrate are approved by the Federal Drug Administration (FDA) as prescription medications to treat bipolar disorder and other mood disorders. They act as mood stabilizers, which can help regulate changes between high mood (mania) and low mood (depression).
While most commonly used to treat bipolar disorder, lithium also hasbeen used off-label for neutropenia, depression, vascular headaches, Huntington’s disease, and more.
Despite its various uses, all forms of lithium are known for their delayed initial onset. According to the National Health Service (NHS), lithium can take anywhere from a week to months to take effect when it is taken initially.
Once lithium takes effect, its half-life ranges from 18-36 hours, implying that a single dose can stay in our system for up to 72 hours. However, we don’t see the peak effects of lithium until about five hours after ingestion, depending on the form and dosage. To maintain consistent efficacy throughout the day, doctors prescribe lithium to be taken at regular intervals.
This means that our first dose will still be lingering in our system when it’s time to take the second dose, which is why it’s difficult to pinpoint exactly how long it takes our body to eliminate lithium. It may take a week or more to be eliminated. So, is it okay to drink after a week of not taking lithium?
Before we’re able to determine if we can drink during and after taking lithium, let’s first understand how alcohol can interfere with our mood, which lithium is commonly prescribed to help regulate.
Alcohol affects our mood through chemical messengers in our brain known as neurotransmitters. Serotonin and dopamine are two of the main neurotransmitters that affect our mood.
After drinking, as our body metabolizes and eliminates alcohol, our serotonin and dopamine levels dip, causing more drastic fluctuations in our mood.
Over time, excessive and prolonged drinking can lead to permanent changes in our brain chemistry. Our brain will produce less serotonin and dopamine, which can prolong periods of low mood. Long-term alcohol use is also connected to impairments in our hypothalamic-pituitary-adrenal (HPA) axis, which can decrease our stress tolerance — increasing the risk of more drastic fluctuations in our mood.
These changes in our brain chemistry explain why long-term drinking is associated with mental health conditions such as anxiety, depression, and more. Alcohol and lithium both impact our mood, but how do they interact with each other?
Alcohol interacts with many drugs, including lithium. To determine if we can drink alcohol while taking lithium, let’s better understand the direct interactions between the two.
Alcohol and lithium interact in many different ways, so is it still okay to drink?
Drinking alcohol while taking lithium can be extremely dangerous. This is largely because lithium has a narrow therapeutic index, meaning there’s a small window between an effective dose and a toxic dose of lithium. Even subtle changes in fluid levels caused by drinking alcohol can lead to lithium toxicity — a life-threatening condition.
A study reviewing patients who were admitted to a psychiatric hospital found that 6.8% of patients being administered lithium had toxic levels of lithium at some point during their treatment. This is without any alcohol and in a highly controlled hospital setting. Adding alcohol into the equation (even one drink) can greatly increase the risk of lithium toxicity or other adverse effects.
But what if it’s just one drink? Since alcohol affects each of us differently, it’s difficult to determine a safe amount of alcohol that can be consumed without experiencing any negative effects. It’s best to avoid drinking altogether. Let’s take a closer look at the associated risks.
When alcohol interacts with lithium, our body can experience varying adverse effects. There are four direct consequences of drinking while taking lithium.
While taking lithium, alcohol can lead to many complications, but what about after discontinuing the medication?
The dangers of drinking after discontinuing lithium are less clear than while taking the medication. However, due to alcohol’s negative effects on our mood, it’s not advisable to drink even after discontinuing lithium.
If we choose to drink, it’s best to first consult with a physician. After discontinuing lithium, it may take some time before it’s completely eliminated from our system — making us susceptible to lithium toxicity. Depending on individual circumstances, other medications may also be prescribed — opening the door to other drug interactions. Drinking after taking lithium and while on the medication is not recommended, so how should we go about it?
Lithium and alcohol go together like oil and water. However, with alcohol being such a large aspect of our social culture, we may be faced with the choice of whether or not we should drink when taking lithium. If the situation does arise, there are ways we can prioritize our health and safety.
By following these tips, we can navigate lithium and alcohol consumption safely.
Warning labels on lithium medication may not be entirely clear on whether or not drinking is okay while taking these medications. However, a closer look at the interaction between lithium and alcohol reveals that drinking while taking lithium can lead to serious adverse effects — even in minimal amounts. Fortunately, healthy alternatives and support when needed can help us approach lithium and alcohol safely.
Antihistamines and alcohol are not a great mix, and hydroxyzine is no exception. Find out why in our latest blog!
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app today!
Maybe those seasonal allergies have you sneezing and rubbing your eyes. For some reason, Benadryl just doesn’t cut it, and neither do its second-generation, over-the-counter cousins. Commuters in the train slide away from you thinking you must have a cold, while coworkers give you looks of concern (were you just crying in our morning meeting?).
Or, maybe, life has been stressful lately and you find yourself binge- watching YouTube videos night after night, unable to go to sleep. You know antidepressants and prescription sleep meds are an option, but you’re hesitant to go that route yet.
Is there anything that could help? For many people, it’s hydroxyzine (better known as Vistaril). Developed as an antihistamine, it has gained a reputation as a fairly mild and “user-friendly” antianxiety and insomnia aid. It’s also fairly common for doctors to prescribe hydroxyzine for alcohol withdrawal symptoms. But what about combining hydroxyzine with alcohol? Let’s find out!
Hydroxyzine (Vistaril) is a prescription antihistamine that works by blocking histamine — a substance produced by the body during allergic reactions.
The side effects tend to be pretty mild:
Like many other sedating antihistamines (think Benadryl or Dramamine), hydroxyzine inhibits the action of a neurotransmitter called acetylcholine, which is responsible for memory, learning, motivation, stimulation, and motor control. As a drug class, these anticholinergic medications can cause blurry vision, confusion, urinary retention, and constipation. For that reason, hydroxyzine is generally not prescribed to folks over 65, who might be more sensitive to these effects.
Despite being developed as an antihistamine, hydroxyzine has a couple of other tricks up its sleeve: in addition to blocking histamine, hydroxyzine is a bronchodilator (it opens up our airways) and an antiemetic (keeps us from throwing up), and it’s sometimes used as a mild, fast-acting, antianxiety medication. Because of its versatility, it’s one of the most commonly prescribed drugs in the United States, with nearly 3.4 million Americans taking it as of 2021.
As a result of its somewhat unusual chemical profile and relatively mild side effects, hydroxyzine is a bit more sophisticated than your run-of-the-mill antihistamine. As mentioned earlier, it’s a triple-tasker in the medical arena:
So how does this versatile medication act differently when alcohol is in the mix?
In general, combining alcohol and antihistamines isn’t a good idea, mainly since alcohol enhances the sedative effects while boosting some of the chemical processes that cause allergic reactions in the first place. (For an in-depth look, check out our blog “Can I Drink Alcohol While Taking Allergy Medication?”)
It’s important to note just how impairing some sedating antihistamines truly are. A study in the Annals of Internal Medicine compared driving performance of people taking Benadryl (a first-generation antihistamine) or Allegra (its second-generation cousin) for hay fever with those who had alcohol or a placebo. The subjects were sent off on a pretend road trip in the Iowa Driving Simulator. The result? Those on Benadryl did worse than the subjects who were legally drunk!
Talking about the study, author John Weiler explains, “First-generation antihistamines, such as diphenhydramine, are known to affect driving performance. However, we were surprised to find that this antihistamine has more impact on driving performance than alcohol does.” He goes on to say that "drowsiness was only weakly associated with minimum following distance, steering instability and crossing into the left lane … These results suggest that people should carefully read warning labels on all medications. Even if you do not feel drowsy after taking an antihistamine or alcohol, you may be impaired."
As with other antihistamines, mixing hydroxyzine with alcohol is not a good idea. There are three big reasons for this:
Probably nothing too drastic, but we never know where that line is, so it’s best to err on the side of safety and stay away from booze if you’re taking hydroxyzine.
If you’ve already combined the two and you’re here after a panicked web search, fear not. Start by taking a deep breath (that’s important!). If you’ve had only a couple drinks, took a normal dose of hydroxyzine, and have no known heart issues, you aren’t in serious danger. Rest, take it easy, and stay in bed or on the couch — now isn’t the time to cook a meal, rearrange furniture, or go for a drive.
Stay aware of your body. Notice if you feel like you’re having trouble breathing or if your heart rate starts feeling like it’s playing jazz instead of beating regularly. You’re likely going to be very tired, so it may be best to ask a family member or partner to check in on you for a few hours. If anything feels troubling, seek immediate medical care.
If you’ve had a lot to drink and you took a hydroxyzine dose higher than normal, or if you have a heart rhythm disorder that prolongs your QT interval, seek immediate medical care.
Combining small amounts of alcohol and hydroxyzine isn’t likely to kill us, but it’s definitely not good for us. It increases the chance of something dangerous happening, and when we do this regularly, it can cause chronic damage to our body.
Whatever condition we’re taking hydroxyzine for, chances are alcohol isn’t doing us any favors when it comes to getting relief. There’s scientific evidence proving that booze has a negative impact on all three conditions we might be taking hydroxyzine for: allergies, anxiety, and insomnia.
Finally, what about using hydroxyzine for alcohol withdrawal? Indeed, it’s one of the ways doctors help patients reduce anxiety and tremors associated with suddenly stopping alcohol use. The neurochemical trainwreck alcohol leaves in its wake manifests as intense anxiety and the notorious “shakes” that sometimes escalate into full-blown seizures. To make this period a bit more comfortable, benzodiazepines are often the go-to form of treatment. One major problem? They’re just as addictive as alcohol itself.
Antihistamines, on the other hand, offer a safer alternative. An article from the Encyclopedia of Sleep explains, “Antihistamines are commonly used in alleviation of insomnia in drug and alcohol withdrawal where traditional GABA-acting hypnotics are less suitable due to the risk of cross-dependence, although there have been no controlled trials in this setting.”
Finally, here are a few tips for staying safe when it comes to alcohol and hydroxyzine.
All in all, dealing with allergies, anxiety, and insomnia alike is no picnic — and there are plenty of people who share your struggles and sympathize. But adding alcohol to the mix is bound to make things even tougher in the long run. Instead, try to see this situation as an opportunity to explore what true wellness is all about. As A.J. Jacobs writes in Drop Dead Healthy: One Man's Humble Quest for Bodily Perfection, “The key to making healthy decisions is to respect your future self. Honor him or her. Treat him or her like you would treat a friend or a loved one.”
Maybe those seasonal allergies have you sneezing and rubbing your eyes. For some reason, Benadryl just doesn’t cut it, and neither do its second-generation, over-the-counter cousins. Commuters in the train slide away from you thinking you must have a cold, while coworkers give you looks of concern (were you just crying in our morning meeting?).
Or, maybe, life has been stressful lately and you find yourself binge- watching YouTube videos night after night, unable to go to sleep. You know antidepressants and prescription sleep meds are an option, but you’re hesitant to go that route yet.
Is there anything that could help? For many people, it’s hydroxyzine (better known as Vistaril). Developed as an antihistamine, it has gained a reputation as a fairly mild and “user-friendly” antianxiety and insomnia aid. It’s also fairly common for doctors to prescribe hydroxyzine for alcohol withdrawal symptoms. But what about combining hydroxyzine with alcohol? Let’s find out!
Hydroxyzine (Vistaril) is a prescription antihistamine that works by blocking histamine — a substance produced by the body during allergic reactions.
The side effects tend to be pretty mild:
Like many other sedating antihistamines (think Benadryl or Dramamine), hydroxyzine inhibits the action of a neurotransmitter called acetylcholine, which is responsible for memory, learning, motivation, stimulation, and motor control. As a drug class, these anticholinergic medications can cause blurry vision, confusion, urinary retention, and constipation. For that reason, hydroxyzine is generally not prescribed to folks over 65, who might be more sensitive to these effects.
Despite being developed as an antihistamine, hydroxyzine has a couple of other tricks up its sleeve: in addition to blocking histamine, hydroxyzine is a bronchodilator (it opens up our airways) and an antiemetic (keeps us from throwing up), and it’s sometimes used as a mild, fast-acting, antianxiety medication. Because of its versatility, it’s one of the most commonly prescribed drugs in the United States, with nearly 3.4 million Americans taking it as of 2021.
As a result of its somewhat unusual chemical profile and relatively mild side effects, hydroxyzine is a bit more sophisticated than your run-of-the-mill antihistamine. As mentioned earlier, it’s a triple-tasker in the medical arena:
So how does this versatile medication act differently when alcohol is in the mix?
In general, combining alcohol and antihistamines isn’t a good idea, mainly since alcohol enhances the sedative effects while boosting some of the chemical processes that cause allergic reactions in the first place. (For an in-depth look, check out our blog “Can I Drink Alcohol While Taking Allergy Medication?”)
It’s important to note just how impairing some sedating antihistamines truly are. A study in the Annals of Internal Medicine compared driving performance of people taking Benadryl (a first-generation antihistamine) or Allegra (its second-generation cousin) for hay fever with those who had alcohol or a placebo. The subjects were sent off on a pretend road trip in the Iowa Driving Simulator. The result? Those on Benadryl did worse than the subjects who were legally drunk!
Talking about the study, author John Weiler explains, “First-generation antihistamines, such as diphenhydramine, are known to affect driving performance. However, we were surprised to find that this antihistamine has more impact on driving performance than alcohol does.” He goes on to say that "drowsiness was only weakly associated with minimum following distance, steering instability and crossing into the left lane … These results suggest that people should carefully read warning labels on all medications. Even if you do not feel drowsy after taking an antihistamine or alcohol, you may be impaired."
As with other antihistamines, mixing hydroxyzine with alcohol is not a good idea. There are three big reasons for this:
Probably nothing too drastic, but we never know where that line is, so it’s best to err on the side of safety and stay away from booze if you’re taking hydroxyzine.
If you’ve already combined the two and you’re here after a panicked web search, fear not. Start by taking a deep breath (that’s important!). If you’ve had only a couple drinks, took a normal dose of hydroxyzine, and have no known heart issues, you aren’t in serious danger. Rest, take it easy, and stay in bed or on the couch — now isn’t the time to cook a meal, rearrange furniture, or go for a drive.
Stay aware of your body. Notice if you feel like you’re having trouble breathing or if your heart rate starts feeling like it’s playing jazz instead of beating regularly. You’re likely going to be very tired, so it may be best to ask a family member or partner to check in on you for a few hours. If anything feels troubling, seek immediate medical care.
If you’ve had a lot to drink and you took a hydroxyzine dose higher than normal, or if you have a heart rhythm disorder that prolongs your QT interval, seek immediate medical care.
Combining small amounts of alcohol and hydroxyzine isn’t likely to kill us, but it’s definitely not good for us. It increases the chance of something dangerous happening, and when we do this regularly, it can cause chronic damage to our body.
Whatever condition we’re taking hydroxyzine for, chances are alcohol isn’t doing us any favors when it comes to getting relief. There’s scientific evidence proving that booze has a negative impact on all three conditions we might be taking hydroxyzine for: allergies, anxiety, and insomnia.
Finally, what about using hydroxyzine for alcohol withdrawal? Indeed, it’s one of the ways doctors help patients reduce anxiety and tremors associated with suddenly stopping alcohol use. The neurochemical trainwreck alcohol leaves in its wake manifests as intense anxiety and the notorious “shakes” that sometimes escalate into full-blown seizures. To make this period a bit more comfortable, benzodiazepines are often the go-to form of treatment. One major problem? They’re just as addictive as alcohol itself.
Antihistamines, on the other hand, offer a safer alternative. An article from the Encyclopedia of Sleep explains, “Antihistamines are commonly used in alleviation of insomnia in drug and alcohol withdrawal where traditional GABA-acting hypnotics are less suitable due to the risk of cross-dependence, although there have been no controlled trials in this setting.”
Finally, here are a few tips for staying safe when it comes to alcohol and hydroxyzine.
All in all, dealing with allergies, anxiety, and insomnia alike is no picnic — and there are plenty of people who share your struggles and sympathize. But adding alcohol to the mix is bound to make things even tougher in the long run. Instead, try to see this situation as an opportunity to explore what true wellness is all about. As A.J. Jacobs writes in Drop Dead Healthy: One Man's Humble Quest for Bodily Perfection, “The key to making healthy decisions is to respect your future self. Honor him or her. Treat him or her like you would treat a friend or a loved one.”
Should you stay away from alcohol while taking Sudafed? Find out why combining the two can amp up the side effects and create a gnarly mix.
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app today!
There’s a meme that describes the problem of sinus infections to a T: “You just don’t appreciate breathing out of both nostrils until one suddenly is taken away from you.” And boy, does that ring true!
Many of us find that Sudafed can be a godsend when it comes to clearing up congestion. But what happens if we add alcohol to the mix? Can you drink on Sudafed? What are the interactions between the active ingredient, pseudoephedrine, and alcohol? Let’s find out!
The active ingredient in Sudafed — pseudoephedrine — has raised some eyebrows over the years, but remains an effective way to clear up that pesky sinus congestion. Structurally similar to the more potent ephedrine, it’s a stimulant from the phenethylamine and amphetamine chemical classes.
Both pseudoephedrine and ephedrine are found naturally in the ephedra plant, which has a long history of medicinal use in Eastern traditions. It works by shrinking swollen mucous membranes in the nose, reducing congestion that often comes with colds or allergies. While it is widely used and generally safe (when used correctly), it can also have some gnarly side effects:
Some folks misuse the drug for its stimulant properties, which can cause even more side effects. Even worse, some will use it to “cook” methamphetamines. This is why you have to show an ID to get it at the drugstore.
Now that we have a better idea of what Sudafed is and how it works, we can see why mixing it with booze is asking for trouble. The combination can cause many problems, mentally and physically.
Since alcohol is a depressant and Sudafed is a stimulant, the combination of the two confuses our central nervous system and cardiovascular system, compounding symptoms:
While a single drink taken with Sudafed probably won’t harm you, it’s never a good idea to mix the two, since we don’t know exactly where the line between safety and harm is. There are lots of factors involved, such as age, metabolism, genetics, what you’ve eaten that day, and what other medications you might be taking. It’s always best to stay on the safe side! Besides, the side effects of the mix, as well as the fact that your symptoms might get worse, would probably make the experience pretty unpleasant.
Finally, here’s a bit of advice for taking Sudafed and staying away from booze in the meantime (or even longer!).
Life has its ups and downs, but adding artificial ones by mixing Sudafed and alcohol can spell trouble. Instead, let’s focus on taking care of our mind and body and discover healthier ways to manage our mood and relax, especially as we heal from an illness. There’s plenty of booze-free fun to be had whether we’re currently taking Sudafed or we reach the other side of whatever has us taking it in the first place.
There’s a meme that describes the problem of sinus infections to a T: “You just don’t appreciate breathing out of both nostrils until one suddenly is taken away from you.” And boy, does that ring true!
Many of us find that Sudafed can be a godsend when it comes to clearing up congestion. But what happens if we add alcohol to the mix? Can you drink on Sudafed? What are the interactions between the active ingredient, pseudoephedrine, and alcohol? Let’s find out!
The active ingredient in Sudafed — pseudoephedrine — has raised some eyebrows over the years, but remains an effective way to clear up that pesky sinus congestion. Structurally similar to the more potent ephedrine, it’s a stimulant from the phenethylamine and amphetamine chemical classes.
Both pseudoephedrine and ephedrine are found naturally in the ephedra plant, which has a long history of medicinal use in Eastern traditions. It works by shrinking swollen mucous membranes in the nose, reducing congestion that often comes with colds or allergies. While it is widely used and generally safe (when used correctly), it can also have some gnarly side effects:
Some folks misuse the drug for its stimulant properties, which can cause even more side effects. Even worse, some will use it to “cook” methamphetamines. This is why you have to show an ID to get it at the drugstore.
Now that we have a better idea of what Sudafed is and how it works, we can see why mixing it with booze is asking for trouble. The combination can cause many problems, mentally and physically.
Since alcohol is a depressant and Sudafed is a stimulant, the combination of the two confuses our central nervous system and cardiovascular system, compounding symptoms:
While a single drink taken with Sudafed probably won’t harm you, it’s never a good idea to mix the two, since we don’t know exactly where the line between safety and harm is. There are lots of factors involved, such as age, metabolism, genetics, what you’ve eaten that day, and what other medications you might be taking. It’s always best to stay on the safe side! Besides, the side effects of the mix, as well as the fact that your symptoms might get worse, would probably make the experience pretty unpleasant.
Finally, here’s a bit of advice for taking Sudafed and staying away from booze in the meantime (or even longer!).
Life has its ups and downs, but adding artificial ones by mixing Sudafed and alcohol can spell trouble. Instead, let’s focus on taking care of our mind and body and discover healthier ways to manage our mood and relax, especially as we heal from an illness. There’s plenty of booze-free fun to be had whether we’re currently taking Sudafed or we reach the other side of whatever has us taking it in the first place.
