Alcohol Consumption and Changes in the Brain
![Reframe App Logo](https://cdn.prod.website-files.com/60d10433104bca13abce2c13/6524611f0bc6ca7db5aea21b_logo.webp)
As Daniel Amen writes in Change Your Brain, Change Your Body: Use Your Brain to Get and Keep the Body You Have Always Wanted, “Your brain is involved in everything you do, every decision you make, every bite of food you take, every cigarette you smoke, every worrisome thought you have, every workout you skip, every alcoholic beverage you drink, and more.”
And yet, the brain is also affected by all of those activities, and it changes based on what we put into our bodies. When it comes to alcohol, these changes can be quite significant, involving everything from temporary shifts to long-term wiring and structural changes, all of which can profoundly affect our experience of the world.
The brain is a bustling hub of activity, with billions of neurons zipping messages around — 24/7! When alcohol enters this dynamic environment, it has immediate effects, as well as ones that linger the following day. Let’s start by exploring these temporary shifts, which involve four types of neurotransmitters, the chemical messengers that keep the brain buzzing with activity and regulate our mood, behavior, and physical experience.
Seconds after that first sip, alcohol travels through our bloodstream and crosses the blood-brain barrier. It starts influencing the brain immediately. It magnifies the release of dopamine, a neurotransmitter responsible for feelings of pleasure and reward. That's why that first sip can sometimes feel so satisfying.
The initial surge of dopamine is strongest at the onset of alcohol consumption. As we continue to drink, however, the dopamine system doesn’t continue to release at the same heightened level. It means the euphoric feelings tied to dopamine might begin to plateau or even diminish with subsequent drinks. That's why the first drink often feels the most rewarding, and there's a diminishing return of that "high" with more booze.
While the initial sips of an alcoholic beverage bring a rush of dopamine (and the euphoria that comes with it), alcohol's broader effects on the brain are a bit more intricate. Alcohol is classified as a central nervous system depressant. But what does this mean, and how do GABA and glutamate come into play?
First things first: the term "depressant" doesn’t imply that it makes one feel depressed emotionally — instead, it refers to the slowing or "depressing" of certain brain functions. Alcohol dampens the speed of neurotransmission, decreases the excitability of neurons, and results in a slowdown of physical and cognitive functions.
Gamma-aminobutyric acid, or GABA as it's more conveniently known, is the chief inhibitory neurotransmitter in the brain. It’s the brain's natural "chill pill,” reducing neuronal excitability and promoting calmness and relaxation. Alcohol boosts the effects of GABA, leading to increased drowsiness, slowed reaction times, and the familiar relaxation associated with drinking.
On the opposite end of the spectrum from GABA is glutamate, the primary excitatory neurotransmitter: it speeds up transmissions and enhances brain activity. Alcohol inhibits glutamate's excitatory signals, contributing to the overall depressant effects on the central nervous system.
With GABA's effects boosted and glutamate's effects suppressed, the net result is a pronounced slowing down of the brain's activities. This is why consuming alcohol leads to slurred speech, decreased motor coordination, drowsiness, blurry vision, and impaired judgment.
Ever had one of those nights where memories are fuzzy, or there are blank patches from the evening? Alcohol also impedes our brain's ability to form new long-term memories. It doesn’t erase them, but it does blur the recording process, making it hard to recall specific events.
When discussing alcohol's effects on the brain, the spotlight often shines on neurotransmitters like dopamine, GABA, and glutamate. But there’s another key player: dynorphin. It’s not as commonly known as the others, but understanding dynorphin offers a more comprehensive picture of the brain-alcohol relationship.
Dynorphin is a type of endogenous opioid peptide, which is naturally produced in the brain and binds to opioid receptors, much as endorphins do. But unlike endorphins, which are often associated with feelings of pleasure and euphoria (think of the “runner’s high”), dynorphin produces the opposite effect. It's often linked with feelings of dysphoria or general unease.
How does alcohol act upon dynorphin? When we drink — especially in larger quantities — a dopamine surge creates feelings of pleasure and reward. However, in an effort to maintain equilibrium, the brain releases dynorphin as a countermeasure to dampen and balance the dopamine, ensuring that the euphoria we feel doesn’t go over the top.
Beyond its interaction with alcohol, elevated dynorphin levels have implications for mood and mental well-being. Over time, as the brain gets accustomed to regular and high levels of alcohol intake, it produces more and more dynorphin to counteract our heightened dopamine levels. This contributes to a reduced sense of pleasure or reward from alcohol and other activities, leading us to consume even more alcohol in an attempt to chase the diminished highs — a cycle that is a crucial factor in the development of dependence and addiction.
With regular heavy drinking, the brain adapts to this new alcohol-infused environment. It begins to expect alcohol's presence, leading to increased tolerance and dependence.
Alcohol dependence isn't just about consuming more drinks or feeling a craving — it signifies a profound adaptation within the brain, which reorganizes itself and adjusts its baseline functioning. This alteration goes beyond behavior; it encompasses structural and chemical changes that redefine the brain's "normal”:
When someone who has been drinking heavily for a while reduces or ends alcohol consumption, the brain throws a bit of a "where's my drink?" tantrum. Let's explore this reaction and the brain-related symptoms that arise during withdrawal.
Consistent high levels of alcohol intake can lead to some troublesome changes in our brains. Just like how constant sun exposure can affect our skin, chronic drinking has some lasting impacts on our brain's landscape. Let's demystify these changes and their implications:
Despite the negative effects, our brains have an astonishing ability to heal. Reducing alcohol or quitting altogether can lead to improvements in cognitive function and a reduction in structural brain damage over time. Plus, the body is programmed to heal, so when we cut back or quit, it jumps into repair mode, mending the damage.
In the words of Neil deGrasse Tyson, “Everything we do, every thought we've ever had, is produced by the human brain. But exactly how it operates remains one of the biggest unsolved mysteries, and it seems the more we probe its secrets, the more surprises we find.”
Our brains are marvels, constantly working, adapting, and helping us navigate our world, and it’s crucial to be aware of the effects of what we consume on them. With a mindful approach, you can make informed decisions about your alcohol consumption. While it might take a bit of effort at first, it’s worth it in the end — after all, the decisions we make today shape our experiences and memories for years to come!
1. What happens in the brain when I take my first sip of alcohol?
Upon taking the initial sip, there's a surge in dopamine, the "feel-good" neurotransmitter, leading to feelings of pleasure and satisfaction. This is often described as the initial buzz or euphoria.
2. How does alcohol act as a depressant in the brain?
Alcohol enhances the effects of GABA, a neurotransmitter that promotes calmness, and inhibits the function of glutamate, an excitatory neurotransmitter. The combined action slows down brain activity, making alcohol a central nervous system depressant.
3. Why might I not remember parts of my evening after drinking?
Alcohol impedes the brain's ability to form new long-term memories. While it doesn't erase memories, it can interfere with the recording process, leading to fuzzy or missing memories from events while intoxicated.
4. How does alcohol affect emotions?
Beyond the pleasurable feelings from dopamine, alcohol's influence on other parts of the brain can amplify a range of emotions. This can lead to exaggerated feelings, from happiness to sadness, during alcohol consumption.
5. Can the brain recover from the effects of alcohol if I reduce or quit drinking?
Yes, the brain has an impressive ability to heal. Reducing or quitting alcohol consumption can result in cognitive improvements and a decrease in structural brain damage over time.
6. What's dynorphin and how does it relate to alcohol?
Dynorphin is a neurotransmitter that counterbalances the pleasurable effects of dopamine. With alcohol consumption, especially chronic use, the brain releases more dynorphin to offset the dopamine surge, which can lead to a reduced sense of pleasure over time.
7. How does alcohol influence the development of dependence or addiction?
With consistent, heavy drinking, the brain adapts to the alcohol-infused environment, increasing tolerance and dependence. Over time, increased dynorphin release can diminish the pleasure from alcohol, leading individuals to consume more in pursuit of the same high, which can contribute to dependence and addiction.
Although it isn’t a treatment for alcohol use disorder (AUD), the Reframe app can help you cut back on drinking gradually, with the science-backed knowledge to empower you 100% of the way. Our proven program has helped millions of people around the world drink less and live more. And we want to help you get there, too!
The Reframe app equips you with the knowledge and skills you need to not only survive drinking less, but to thrive while you navigate the journey. Our daily research-backed readings teach you the neuroscience of alcohol, and our in-app Toolkit provides the resources and activities you need to navigate each challenge.
You’ll meet millions of fellow Reframers in our 24/7 Forum chat and daily Zoom check-in meetings. Receive encouragement from people worldwide who know exactly what you’re going through! You’ll also have the opportunity to connect with our licensed Reframe coaches for more personalized guidance.
Plus, we’re always introducing new features to optimize your in-app experience. We recently launched our in-app chatbot, Melody, powered by the world’s most powerful AI technology. Melody is here to help as you adjust to a life with less (or no) alcohol.
And that’s not all! Every month, we launch fun challenges, like Dry/Damp January, Mental Health May, and Outdoorsy June. You won’t want to miss out on the chance to participate alongside fellow Reframers (or solo if that’s more your thing!).
The Reframe app is free for 7 days, so you don’t have anything to lose by trying it. Are you ready to feel empowered and discover life beyond alcohol? Then download our app through the App Store or Google Play today!
Reframe supports you in reducing alcohol consumption and enhancing your well-being.